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Invitrogen
BAZ2A Polyclonal Antibody
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产品信息
PA5-66636
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human TIP5
偶联物
形式
Liquid
浓度
0.7 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: SLEVPLTASVT SPKASPVTSP AAAFPTASPA NKDVSSFLET TADVEEITGE GLTASGSGDV MRRRIATPEE VRLPLQHGWR REVRIKKGSH R
Highest antigen sequence identity to the following orthologs - mouse 71%, rat 63%.
靶标信息
TIP 5 is the large subunit of the nucleolar remodeling complex NoRC. NoRC causes the repression of ribosomal gene transcription. It was demonstrated that histone deacetylation is involved in this repression and that TIP5 is associated with the histone deacetylase HDAC1 and mediates the deacetylation of histones in the vicinity of the rDNA promoter. The interaction of TIP5 and HDAC1, which is necessary for transcriptional repression, is established by the C-terminal PHD finger and bromodomain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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