This antibody is predicted to react with bovine, canine, human and porcine based on sequence homology.
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.
蛋白别名: breast cancer anti-estrogen resistance protein 3; Breast cancer anti-estrogen resistance protein 3 homolog; KIAA0554; OTTHUMP00000011961; p130Cas-binding protein AND-34
基因别名: AI131758; AND-34; And34; Bcar3
UniProt ID: (Mouse) Q9QZK2
Entrez Gene ID: (Mouse) 29815