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AbboMax
BCL-w Polyclonal Antibody
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产品信息
602-950
产品规格
种属反应
Bovine,
Dog,
Chicken,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide derived from N-terminus of human BCL-W protein
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with proprietary stabilizer
内含物
0.01% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive control: Breast carcinoma
Cellular location: Mitochondria outer membrane, Nucleus membrane.
靶标信息
Using a PCR-based strategy, an additional protein with life-promoting activity, designated Bcl-w, has been identified. The protein is highly conserved between mouse and human and is encoded by a gene located near the TCRalpha gene on chromosome 14. Bcl-w is expressed in myeloid cell lines but not in T and B lymphocytes, and can be found in a wide range of tissues. An alternative splicing event in exon 4 results in two transcripts. The first, Bcl-w, encodes a protein of 193 amino acids, and the second, Bcl-w/rox, encodes a protein 333 amino acids in length. The "rox" portion of Bcl-w/rox shows a striking 66% amino acid sequence identity with the Drosophila rox2 protein; however, the Bcl-w/rox transcript may be expressed at very low levels.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: anti-apoptotic member of Bcl-2 family; BCL2L2; Apoptosis regulator Bcl-W; Bcl-2-like protein 2; Bcl2-L-2; BCL2-like 2 protein; Bcl2-like protein 2; c98; protein phosphatase 1, regulatory subunit 51; v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
基因别名: AW048834; BCL-W; BCL-WEL; BCL-WS; BCL2-L-2; BCL2L2; BCLW; c98; Gtrgal2; Gtrosa41; KIAA0271; PPP1R51; RELA
UniProt ID: (Human) Q92843, (Bovine) Q1RMX3, (Dog) Q45T69, (Mouse) P70345
Entrez Gene ID: (Human) 599, (Bovine) 767601, (Dog) 490611, (Mouse) 12050, (Rat) 60434
spermatogenesis
intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of apoptotic process
Sertoli cell proliferation
extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of intrinsic apoptotic signaling pathway
apoptotic process
regulation of apoptotic process
