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Proteintech
BCOR Polyclonal Antibody
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产品信息
12107-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BCOR Fusion Protein Ag2752 (2-361 aa encoded by BC009675)
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: RFRKRPEPS SDYDLSPAKQ EPKPFDRLQQ LLPASQSTQL PCSSSPQETT QSRPMPPEAR RLIVNKNAGE TLLQRAARLG YEEVVLYCLE NKICDVNHRD NAGYCALHEA CARGWLNIVR HLLEYGADVN CSAQDGTRPL HDAVENDHLE IVRLLLSYGA DPTLATYSGR TIMKMTHSEL MEKFLTDYLN DLQGRNDDDA SGTWDFYGSS VCEPDDESGY DVLANPPGPE DQDDDDDAYS DVFEFEFSET PLLPCYNIQV SVAQGPRNWL LLSDVLKKLK MSSRIFRCNF PNVEIVTIAE AEFYRQVSAS LLFSCSKDLE AFNPESKELL DLVEFTNEIQ TLLGSSVEWL HPSDLASDNY W (2-361 aa encoded by BC009675)
靶标信息
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BCL-6 corepressor; BCL-6 interacting corepressor; Bcl6 interacting corepressor; BCoR
基因别名: 5830466J11Rik; 8430401K06Rik; ANOP2; BCOR; BcorR; D930024N20Rik; KIAA1575; MAA2; MCOPS2; mKIAA1575; RGD1562735
UniProt ID: (Human) Q6W2J9, (Mouse) Q8CGN4
Entrez Gene ID: (Human) 54880, (Rat) 317346, (Mouse) 71458
negative regulation of transcription from RNA polymerase II promoter
negative regulation of histone H3-K36 methylation
heart development
biological_process
negative regulation of bone mineralization
histone H2A monoubiquitination
odontogenesis
negative regulation of transcription, DNA-templated
negative regulation of histone H3-K4 methylation
palate development
specification of axis polarity
negative regulation of tooth mineralization
negative regulation of nucleic acid-templated transcription
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
