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Proteintech
BCR Polyclonal Antibody
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产品信息
22585-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Non-human primate
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BCR Fusion Protein Ag18281 (1-350 aa encoded by BC066122)
偶联物
形式
Liquid
浓度
0.45 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MVDPVGFAE AWKAQFPDSE PPRMELRSVG DIEQELERCK ASIRRLEQEV NQERFRMIYL QTLLAKEKKS YDRQRWGFRR AAQAPDGASE PRASASRPQP APADGADPPP AEEPEARPDG EGSPGKARPG TARRPGAAAS GERDDRGPPA SVAALRSNFE RIRKGHGQPG ADAEKPFYVN VEFHHERGLV KVNDKEVSDR ISSLGSQAMQ MERKKSQHGA GSSVGDASRP PYRGRSSESS CGVDGDYEDA ELNPRFLKDN LIDANGGSRP PWPPLEYQPY QSIYVGGMME GEGKGPLLRS QSTSEQEKRL TWPRRSYSPR SFEDCGGGYT PDCSSNENLT SSEEDFSSGQ S (1-350 aa encoded by BC066122)
靶标信息
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ABL; BCR protein; bcr/abl; BCR/FGFR1 chimera protein; breakpoint cluster region; Breakpoint cluster region protein; c-ABL; c-abl oncogene 1; EC 2.7.11.1; FGFR1/BCR chimera protein; JTK7; p150; Renal carcinoma antigen NY-REN-26; RP11-83J21.1; v-abl
基因别名: ALL; BCR; BCR1; CML; D22S11; D22S662; PHL
UniProt ID: (Human) P11274
Entrez Gene ID: (Human) 613
negative regulation of cellular extravasation
protein phosphorylation
signal transduction
brain development
peptidyl-tyrosine phosphorylation
actin cytoskeleton organization
response to lipopolysaccharide
regulation of Rho protein signal transduction
intracellular signal transduction
inner ear morphogenesis
regulation of vascular permeability
negative regulation of neutrophil degranulation
positive regulation of GTPase activity
protein autophosphorylation
platelet-derived growth factor receptor signaling pathway
negative regulation of inflammatory response
positive regulation of phagocytosis
neuromuscular process controlling balance
regulation of small GTPase mediated signal transduction
regulation of cell cycle
negative regulation of blood vessel remodeling
