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Proteintech
BLVRA Polyclonal Antibody
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产品信息
10775-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BLVRA Fusion Protein Ag1166 (1-296 aa encoded by BC008456)
偶联物
形式
Liquid
浓度
0.43 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MNAEPERKF GVVVVGVGRA GSVRMRDLRN PHPSSAFLNL IGFVSRRELG SIDGVQQISL EDALSSQEVE VAYICSESSS HEDYIRQFLN AGKHVLVEYP MTLSLAAAQE LWELAEQKGK VLHEEHVELL MEEFAFLKKE VVGKDLLKGS LLFTAGPLEE ERFGFPAFSG ISRLTWLVSL FGELSLVSAT LEERKEDQYM KMTVCLETEK KSPLSWIEEK GPGLKRNRYL SFHFKSGSLE NVPNVGVNKN IFLKDQNIFV QKLLGQFSEK ELAAEKKRIL HCLGLAEEIQ KYCCSRK (1-296 aa encoded by BC008456)
靶标信息
Biliverdin reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, an enzyme that converts heme to iron, carbon monoxide, and biliverdin. BLVR is unique among all enzymes to date in being dual pH/dual cofactor-dependent, as it requires NADH (pH 6.7) or NADPH (pH 8.7) as an electron donor. There are two isoforms of BLVR, biliverdin-IX alpha-reductase (BLVRA), the major component of human adult liver, and biliverdin-IX beta-reductase (BLVRB), found predominantly in fetal liver. The product of BLVR, bilirubin, is an important biological antioxidant, however it is also a neurotoxin and the cause of kernicterus. In addition to being an antioxidant, it inhibits kinase activity and the activity of enzymes such as protein kinase C and NADPH oxidase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Biliverdin reductase A; Biliverdin-IX alpha-reductase; BVR A; EC 1.3.1.24; testis tissue sperm-binding protein Li 61n
基因别名: 0610006A11Rik; 2500001N03Rik; BLVR; BLVRA; BVR; BVRA
UniProt ID: (Human) O95019, (Mouse) Q9CY64
Entrez Gene ID: (Human) 644, (Mouse) 109778
