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BMAL1 Polyclonal Antibody
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图: 1 / 2
BMAL1 Antibody (600-101-ML8) in ICC/IF
Immunofluorescence of Goat anti-BMAL1 Antibody. Cell Line: HeLa Cells. Fixative: 4%PFA. Permeabilization: 0.3% Triton X-100. Primary Antibody: Anti-BMAL1 at 15µg/mL overnight at 2-8°C. Secondary antibody: Donkey Anti-Goat IgG DyLight™488 (p/n 605-741-125) at 15µg/mL at RT for 1 hr. Nuclear Counterstain: DAPI. Image Staining: (A) DAPI. (B) Anit-BMAL1 + secondary. (C) merge A+B. (D) secondary only.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
600-101-ML8
产品规格
种属反应
Human,
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-BMAL1 antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to a N-terminal portion of human Bmal1 conjugated to Keyhole Limpet Hemocyanin (KLH).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.92 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
内含物
0.01% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This affinity purified antibody is directed against human Bmal1. A BLAST analysis was used to suggest cross-reactivity with the antigen based on 100% homology with the immunizing sequence to mouse, rat, golden hamster, horse, gallus gallus, Pongo abelii, Tyto alba, and Nannospalax galili.
靶标信息
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Arnt3; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic helix-loop-helix ARNT-like protein 1; Basic-helix-loop-helix-PAS protein MOP3; bHLH-PAS protein JAP3; bHLHe5; Brain and muscle ARNT-like 1; CG8727 PA; Class E basic helix-loop-helix protein 5; cycle; Member of PAS protein 3; MGC47515; PAS domain-containing protein 3
基因别名: Arnt3; ARNTL; BHLHE5; BMAL1; BMAL1b; bmal1b'; MOP3; PASD3
UniProt ID: (Mouse) Q9WTL8
Entrez Gene ID: (Mouse) 11865
transcription regulatory region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
core promoter sequence-specific DNA binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription factor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
signal transducer activity
protein binding
transcription factor binding
aryl hydrocarbon receptor binding
bHLH transcription factor binding
sequence-specific DNA binding
protein heterodimerization activity
protein dimerization activity
Hsp90 protein binding
E-box binding
basic helix-loop-helix transcription factor
protein import into nucleus, translocation
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
signal transduction
spermatogenesis
circadian rhythm
negative regulation of TOR signaling
circadian regulation of gene expression
regulation of protein catabolic process
regulation of hair cycle
positive regulation of circadian rhythm
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of fat cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
regulation of neurogenesis
regulation of insulin secretion
regulation of cell cycle
response to redox state
positive regulation of canonical Wnt signaling pathway
oxidative stress-induced premature senescence
regulation of type B pancreatic cell development
negative regulation of glucocorticoid receptor signaling pathway
regulation of cellular senescence
positive regulation of skeletal muscle cell differentiation
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