Invitrogen

BMP-2 Recombinant Superclonal Antibody (18HCLC)

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2 篇参考文献
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说明书
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产品信息

710022

应用
建议稀释比
已发表文章

免疫印迹 (WB)

4-5 µg/mL
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免疫细胞化学 (ICC/IF)

1 µg/mL
-
产品规格

种属反应

Human

已发表种属

Not Applicable

宿主/亚型

Rabbit / IgG

Expression System

Expi293

分类

Recombinant Superclonal

类型

Antibody

克隆号

18HCLC

抗原

Protein corresponding to amino acids 283-396 of human BMP2
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2532532

产品详细信息

This antibody is predicted to react with mouse based on sequence homology.

Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.

靶标信息

Bone Morphogenic Proteins (BMP) are members of the TGF-beta superfamily that affect bone and cartilage formation (Hogan 1996, Reddi 1998 and Francis-West et al. 1999). Mature BMPs are 30-38 kDa proteins that assume a TGF-beta -like cysteine knot configuration. Lovostatin increases bone formation by turning on the bmp-2 gene (Mundy et al. 1999). BMPs stimulate the production of specific bone matrix proteins and alter stromal cell and osteoclast proliferation (Macias et al. 1999, Lecanda et al. 1997). BMPs may also be an important factor for development of the viscera, with roles in cell proliferation, apoptosis, differentiation, and morphogenesis (Hogan 1996, Dale and Wardle 1999). BMPs appear to be responsible for normal dorsal/ventral patterning. Like TGF-beta, BMPs bind to a type II receptor, which then recruits the transducing type I receptor unit, activating the Smad protein signaling pathway (Massague 1994, Derynck 1997, Attisano 1993).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

#

生物信息学

蛋白别名: 2610024H22Rik; AL117858; AW546137; BB189135; BMP; BMP-2; BMP-2A; BMPR-II; BMPRII; Bone morphogenetic protein; Bone morphogenetic protein 2; Bone morphogenetic protein 2A; H-BMP-2

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基因别名: BDA2; BMP2; BMP2A

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UniProt ID: (Human) P12643

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Entrez Gene ID: (Human) 650

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功能
retinol dehydrogenase activity receptor binding cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity phosphatase activator activity co-receptor binding SMAD binding protein heterodimerization activity BMP receptor binding growth factor
参与通路
negative regulation of transcription from RNA polymerase II promoter activation of MAPK activity skeletal system development osteoblast differentiation branching involved in ureteric bud morphogenesis response to hypoxia in utero embryonic development epithelial to mesenchymal transition positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation chondrocyte differentiation BMP signaling pathway involved in heart induction atrioventricular valve morphogenesis endocardial cushion morphogenesis negative regulation of Wnt signaling pathway involved in heart development proteoglycan metabolic process regulation of transcription, DNA-templated protein phosphorylation inflammatory response Notch signaling pathway cell-cell signaling heart development negative regulation of cell proliferation embryo development organ morphogenesis positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of steroid biosynthetic process positive regulation of phosphatase activity telencephalon development telencephalon regionalization positive regulation of Wnt signaling pathway bone mineralization positive regulation of cell migration positive regulation of bone mineralization BMP signaling pathway protein destabilization positive regulation of protein binding negative regulation of aldosterone biosynthetic process positive regulation of osteoblast proliferation cardiocyte differentiation embryonic heart tube anterior/posterior pattern specification bone mineralization involved in bone maturation growth odontogenesis of dentin-containing tooth positive regulation of odontogenesis regulation of odontogenesis of dentin-containing tooth positive regulation of apoptotic process positive regulation of MAPK cascade negative regulation of insulin-like growth factor receptor signaling pathway cell fate commitment positive regulation of fat cell differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of astrocyte differentiation mesenchymal cell differentiation inner ear development negative regulation of calcium-independent cell-cell adhesion cardiac muscle cell differentiation cardiac muscle tissue morphogenesis oxidation-reduction process pericardium development corticotropin hormone secreting cell differentiation thyroid-stimulating hormone-secreting cell differentiation cardiac epithelial to mesenchymal transition pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction mesenchyme development positive regulation of Wnt signaling pathway by BMP signaling pathway positive regulation of cartilage development positive regulation of ERK1 and ERK2 cascade cellular response to organic cyclic compound cellular response to BMP stimulus mesenchymal cell proliferation involved in ureteric bud development negative regulation of canonical Wnt signaling pathway positive regulation of p38MAPK cascade positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus negative regulation of cortisol biosynthetic process negative regulation of cardiac muscle cell differentiation
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