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Invitrogen
BNP Polyclonal Antibody
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BNP Antibody (PA5-102596) in ICC/IF
Immunofluorescent analysis of BNP in HepG2. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C) incubated with BNP polyclonal antibody (Product # PA5-102596) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 at a dilution of 1:600.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-102596
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NPPB(Accession P16860), corresponding to amino acid residues A10-E60.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.0 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total NPPB.
靶标信息
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BNP-32; Brain natriuretic factor; Brain natriuretic factor prohormone; brain natriuretic peptide; Gamma-brain natriuretic peptide; Iso-ANP; natriuretic peptide precursor B; natriuretic peptide precursor type B; Natriuretic peptides B; preproBNP; type-B natriuretic factor
基因别名: AA408272; BNF; BNP; NPPB
UniProt ID: (Rat) P13205, (Mouse) P40753
Entrez Gene ID: (Rat) 25105, (Mouse) 18158
response to hypoxia
negative regulation of systemic arterial blood pressure
cGMP biosynthetic process
inflammatory response
receptor guanylyl cyclase signaling pathway
heart development
regulation of blood pressure
response to organic cyclic compound
negative regulation of cell growth
response to lipopolysaccharide
positive regulation of urine volume
positive regulation of renal sodium excretion
response to drug
response to peptide hormone
negative regulation of smooth muscle cell proliferation
regulation of blood vessel size
response to calcium ion
cellular response to mechanical stimulus
positive regulation of collecting lymphatic vessel constriction
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