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Proteintech
BRAP Polyclonal Antibody
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产品信息
27431-1-AP
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BRAP Fusion Protein Ag26728 (376-535 aa encoded by BC136698)
偶联物
形式
Liquid
浓度
0.33 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: RLVASKTDG KIVQYECEGD TCQEEKIDAL QLEYSYLLTS QLESQRIYWE NKIVRIEKDT AEEINNMKTK FKETIEKCDN LEHKLNDLLK EKQSVERKCT QLNTKVAKLT NELKEEQEMN KCLRANQVLL QNKLKEEERV LKETCDQKDL QITEIQEQLR D (376-535 aa encoded by BC136698)
靶标信息
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BRAP; BRAP2; BRCA1-associated protein; galectin-2-binding protein; IMP; Impedes mitogenic signal propagation; Renal carcinoma antigen NY-REN-63; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2
基因别名: BRAP; BRAP2; IMP; RNF52
UniProt ID: (Human) Q7Z569
Entrez Gene ID: (Human) 8315
