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Invitrogen
BRCA1 Monoclonal Antibody (KEN), DyLight™ 550
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产品信息
MA5-16054
产品规格
宿主/亚型
Mouse
/ IgG3, kappa
分类
Monoclonal
类型
Antibody
克隆号
KEN
抗原
Human BRCA1 (residues 1314-1864).
偶联物
激发/发射光谱
556/570 nm
查看光谱
形式
Liquid
浓度
1.67 mg/mL
保存条件
4°C, store in dark
运输条件
Wet ice
RRID
产品详细信息
Suggested positive control: U2OS and MCF-7 whole cell lysates.
靶标信息
BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor in combination with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. The BRCA1 protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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