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Proteintech
BRD7 Polyclonal Antibody
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产品信息
51009-2-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BRD7 Fusion Protein Ag3911 (1-350 aa encoded by BC050728)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MGKKHKKHK SDKHLYEEYV EKPLKLVLKV GGNEVTELST GSSGHDSSLF EDKNDHDKHK DRKRKKRKKG EKQIPGEEKG RKRRRVKEDK KKRDRDRVEN EAEKDLQCHA PVRLDLPPEK PLTSSLAKQE EVEQTPLQEA LNQLMRQLQR KDPSAFFSFP VTDFIAPGYS MIIKHPMDFS TMKEKIKNND YQSIEELKDN FKLMCTNAMI YNKPETIYYK AAKKLLHSGM KILSQERIQS LKQSIDFMAD LQKTRKQKDG TDTSQSGEDG GCWQREREDS GDAEAHAFKS PSKENKKKDK DMLEDKFKSN NLEREQEQLD RIVKESGGKL TRRLVNSQCE FERRKPDGTT T (1-350 aa encoded by BC050728)
靶标信息
BRD7 acts both as coactivator and as corepressor. For example, it activates the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. In addition, it is required for TP53-mediated cell-cycle arrest in response to oncogene activation. BRD7 promotes acetylation of TP53 at Lys-382, and thereby promotes efficient recruitment of TP53 to target promoters, inhibiting cell cycle progression from G1 to S phase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 75 kDa bromodomain protein; bromodomain protein 75 kDa; bromodomain-containing 7; Bromodomain-containing protein 7; Protein CELTIX-1; protein tyrosine phosphatase, non-receptor type 13 interacting protein
基因别名: BP75; BRD7; CELTIX1; NAG4; Ptpn13ip
UniProt ID: (Human) Q9NPI1, (Mouse) O88665
Entrez Gene ID: (Human) 29117, (Mouse) 26992, (Rat) 361374
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell cycle
negative regulation of cell proliferation
Wnt signaling pathway
positive regulation of histone acetylation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
regulation of signal transduction by p53 class mediator
negative regulation of G1/S transition of mitotic cell cycle
regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
biological_process
