This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
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Immunogen sequence: MGKKHKKHKS DKHLYEEYVE KPLKLVLKVG GNEVTELSTG SSGHDSSLFE DKNDHDKHKD RKRKKRKKGE KQIPGEEKGR KRRRVKEDKK KRDRD; Positive Samples: U-87MG, HepG2, SW620; Cellular Location: Nucleus
BRD7 acts both as coactivator and as corepressor. For example, it activates the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. In addition, it is required for TP53-mediated cell-cycle arrest in response to oncogene activation. BRD7 promotes acetylation of TP53 at Lys-382, and thereby promotes efficient recruitment of TP53 to target promoters, inhibiting cell cycle progression from G1 to S phase.
Protein Aliases: 75 kDa bromodomain protein; Bromodomain-containing protein 7; Protein CELTIX-1
Gene Aliases: BP75; BRD7; CELTIX1; NAG4
UniProt ID: (Human) Q9NPI1
Entrez Gene ID: (Human) 29117
Molecular Function: chromatin/chromatin-binding, or -regulatory protein