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Immunogen sequence: MPSEVSEVLS VGGRWTPDLE ITSSQPLDGQ EDKLLHVSSL DTPQRSYGDL SPPCSNWVET GLEVSLTTDE LLYPSPKAGK EVSGHSELLG SLPASS
Highest antigen sequence identity to the following orthologs: Mouse - 68%, Rat - 68%.
Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Acts by facilitating transcription elongation at piRNA loci during pachytene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BTB (POZ) domain containing 18; BTB/POZ domain-containing protein 18; hCG1730474
基因别名: BTBD18
UniProt ID: (Human) B2RXH4
Entrez Gene ID: (Human) 643376