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Fabgennix
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Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BTB (POZ) domain containing 7; BTB/POZ domain-containing protein 7; Function-unkown protein 1
基因别名: 5730507E09Rik; 8030448M07; BTBD7; E130118E17Rik; FUP1; KIAA1525; mKIAA1525
UniProt ID: (Human) Q9P203, (Mouse) Q8CFE5
Entrez Gene ID: (Human) 55727, (Mouse) 238386