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Invitrogen
Immunogen sequence: LLHYLYTGEF GMEDSRFQNV DILVQLSEEF GTPNSLDVDM RGLFDYMCYY DVVLSFSSDS ELVEAFGGNQ NCLDEELKAH KAVISARSPF FRNLLQRRIR TGEE
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 99%.
Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BTB (POZ) domain containing 7; BTB/POZ domain-containing protein 7
基因别名: BTBD7; FUP1; KIAA1525
UniProt ID: (Human) Q9P203
Entrez Gene ID: (Human) 55727
