Bioss

BTG1/BTG2 Polyclonal Antibody

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说明书
实验方案
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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

BS-7526R

应用
建议稀释比
已发表文章

免疫组化（石蜡） (IHC (P))

1:400
-

免疫组化（冰冻） (IHC (F))

1:100-1:500
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human BTG1, amino acids 41-140.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

BTG1 belongs to the BTG family of proteins.FUNCTION: Anti-proliferative protein. Its expression is associated with the early G1 phase of the cell cycle. A chromosomal aberration involving BTG1 may be a cause of a form of B cell chronic lymphocytic leukemia; translocation t(8;12)(q24;q22) with MYC. BTG2 is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. BTG2 is involved in the regulation of the G1/S transition of the cell cycle. It modulates transcription regulation mediated by ESR1 (referenced from Entrez Gene). BTG2 expression is induced in vivo during neurogenesis, and the gene is transiently expressed in vitro in rat pheochromocytoma PC12 cells after induction of neuronal differentiation by addition of nerve growth factor (NGF); suggesting that BTG2 is functionally significant during the neuronal differentiation process (PMID: 12360398).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Anti-proliferative factor; B-cell translocation gene 1 protein; B-cell translocation gene 1, anti-proliferative; B-cell translocation gene 2; B-cell translocation gene 2, anti-proliferative; BTG; BTG family member 2; BTG family, member 2; BTG1/2; cell surface alloantigen; Early induced gene B-cell translocation gene 2; nerve growth factor-inducible anti-proliferative; NGF-inducible anti-proliferative protein PC3; NGF-inducible anti-proliferative putative secreted protein; NGF-inducible protein TIS21; pheochromacytoma cell-3; Protein BTG1; Protein BTG2

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基因别名: AA959598; Agl; AI426953; An; an-1; APRO1; APRO2; AW546738; BTG1; BTG2; PC3; TIS21

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UniProt ID: (Human) P62324, (Human) P78543, (Rat) Q63073, (Mouse) P62325, (Rat) P27049, (Mouse) Q04211

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Entrez Gene ID: (Human) 694, (Human) 7832, (Rat) 29618, (Mouse) 12226, (Rat) 29619, (Mouse) 12227

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功能
transcription cofactor activity protein binding enzyme binding kinase binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
参与通路
regulation of transcription, DNA-templated negative regulation of cell proliferation cell migration negative regulation of cell growth positive regulation of endothelial cell differentiation positive regulation of myoblast differentiation positive regulation of angiogenesis positive regulation of fibroblast apoptotic process protein methylation response to oxidative stress spermatogenesis spermatid development response to peptide hormone positive regulation of catalytic activity negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated cellular response to DNA damage stimulus associative learning response to mechanical stimulus anterior/posterior pattern specification response to organic substance response to organonitrogen compound response to organic cyclic compound negative regulation of translation dentate gyrus development central nervous system neuron development neuron differentiation neuron projection development skeletal muscle cell differentiation negative regulation of apoptotic process negative regulation of neuron apoptotic process response to electrical stimulus positive regulation of nuclear-transcribed mRNA poly(A) tail shortening negative regulation of neural precursor cell proliferation transcription from RNA polymerase II promoter DNA repair DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
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