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Invitrogen
BZLF1 Polyclonal Antibody
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BZLF1 Antibody (PA5-144528) in WB
Western blot analysis of BZLF1 in recombinant protein All lanes: BZLF1 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1:50,000 dilution Predicted band size: 46 kDa Observed band size: 50 kDa. using a dilution of 1:1,000. Samples were incubated with BZLF1 polyclonal antibody (Product # PA5-144528). Secondary: Goat polyclonal to rabbit IgG at 1:50,000 dilution Predicted band size: 46 kDa Observed band size: 50 kDa. Predicted band size: 46 kDa Observed band size: 50 kDa.
产品信息
PA5-144528
产品规格
种属反应
Virus
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Epstein-Barr virus BZLF1 protein
偶联物
形式
Liquid
浓度
4.9 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% Proclin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Transcription factor that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle (PubMed:8404860) (Probable). Mediates the switch from the latent to the lytic cycle of infection in cells containing a highly methylated viral genome (PubMed:34893887, PubMed:15361873). Probably binds to silenced chromatin and recruits host chromatin-remodeling enzymes (PubMed:30926617). Regulates this switch by binding to 2 types of ZEBRA response elements (ZREs): the CpG-free AP-1 like elements (latency) and the methylated CpG-containing elements (lytic replication) (PubMed:34893887, PubMed:22022468) (Probable). Activates preferentially the methylated forms of the viral lytic R (BRLF1) and Na (BRRF1) gene promoters, the latters being the first genes activated during Z-mediated reactivation in latently infected cells (PubMed:19325883, PubMed:15361873). BZLF1 and BRLF1 act together to trigger lytic replication (PubMed:10856251, PubMed:15361873). Also binds the lytic origin of replication, oriLyt (PubMed:20808903). Induces G1 cell cycle arrest by stabilizing the host CCAAT/enhancer binding protein CEBPA (PubMed:15078966). This function is important because the lytic cycle preferentially takes place in host cells arrested in G1 (PubMed:15078966).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Trans-activator protein BZLF1
