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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • BCL-XL Antibodies

          Invitrogen

          Bcl-xL Polyclonal Antibody

          Advanced Verification

          This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.

          1 Published Figure
          2 References
          View all (21) BCL-XL antibodies
          Datasheet
          Protocols
          Tech Support

          Cite Bcl-xL Polyclonal Antibody

          Datasheet
          Protocols
          Tech Support
          • Antibody Testing Data (3)
          • Published Figures (1)
          • Advanced Verification (1)
          Bcl-xL Antibody in Western Blot (WB)
          Group 53 Created with Sketch.

          FIGURE: 1 / 5

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          Bcl-xL Antibody (PA5-17805) in WB

          Western blot was performed using Anti-Bcl-xL Polyclonal Antibody(Product # PA5-17805) and a 25kDa band corresponding to Bcl-xL was observed across cell lines tested. Whole cell extracts (30 µg lysate) of A-431 (Lane 1), NIH:OVCAR-3 (Lane 2), Hep G2 (Lane 3), NIH/3T3 (Lane 4), PC-12 (Lane 5), A549 (Lane 6) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot ... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
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          Product Details

          PA5-17805

          Applications
          Tested Dilution
          Publications

          免疫印迹 (WB)

          1:1,000
          查看1篇已发表文章 1篇已发表文章

          免疫组化 (IHC)

          -
          查看1篇已发表文章 1篇已发表文章

          免疫细胞化学 (ICC/IF)

          5 µg
          -

          免疫沉淀 (IP)

          1:50
          -
          产品规格

          Species Reactivity

          Human, Mouse, Non-human primate, Rat

          Published species

          Rat

          Host/Isotype

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          Immunogen

          Synthetic peptide corresponding to residues surrounding Asp61 of human Bcl-xL
          View immunogen

          Conjugate

          Unconjugated

          形式

          Liquid

          浓度

          82.8 µg/mL

          纯化类型

          Antigen affinity chromatography

          保存液

          0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

          内含物

          no preservative

          保存条件

          -20°C

          RRID

          AB_10977568

          Product Specific Information

          It is not recommended to aliquot this antibody.

          This antibody is not cross-reactive with other Bcl-2 family members.

          Target Information

          BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          Bioinformatics

          Protein Aliases: anti-apoptosis regulatory protein; Apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; Bcl-2-like protein 1; bcl-xS; Bcl2-L-1; BCL2-like 1; BCLXL; BCLXS; DKFZp781P2092; OTTHUMP00000030550; OTTHUMP00000030552; OTTHUMP00000030555; OTTHUMP00000030556; OTTHUMP00000030557; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3

          View more View less

          Gene Aliases: Bcl(X)L; Bcl-X; Bcl-XL; BCL-XL/S; bcl2-L-1; BCL2L; BCL2L1; BCLX; Blc2l; PPP1R52

          View more View less

          UniProt ID: (Human) Q07817, (Mouse) Q64373, (Rat) P53563

          View more View less

          Entrez Gene ID: (Human) 598, (Mouse) 12048, (Rat) 24888

          View more View less

          Function(s)
          cytokinesis ovarian follicle development in utero embryonic development release of cytochrome c from mitochondria endocytosis mitotic cell cycle checkpoint germ cell development spermatogenesis cell proliferation positive regulation of cell proliferation male gonad development intrinsic apoptotic signaling pathway in response to DNA damage apoptotic mitochondrial changes fertilization suppression by virus of host apoptotic process response to cytokine growth negative regulation of apoptotic process negative regulation of neuron apoptotic process response to cycloheximide regulation of mitochondrial membrane permeability neuron apoptotic process regulation of mitochondrial membrane potential cellular process regulating host cell cycle in response to virus mitochondrion morphogenesis cellular response to amino acid stimulus cellular response to alkaloid cellular response to gamma radiation apoptotic process in bone marrow negative regulation of establishment of protein localization to plasma membrane negative regulation of release of cytochrome c from mitochondria extrinsic apoptotic signaling pathway in absence of ligand hepatocyte apoptotic process negative regulation of execution phase of apoptosis negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of extrinsic apoptotic signaling pathway in absence of ligand negative regulation of intrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway response to ischemia apoptotic process response to radiation response to virus regulation of apoptotic process positive regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of anoikis response to hypoxia response to oxidative stress response to inorganic substance response to organonitrogen compound response to lead ion response to organic cyclic compound response to hydrogen peroxide response to peptide hormone response to electrical stimulus
          Process(es)
          protein binding protein kinase binding identical protein binding protein homodimerization activity protein heterodimerization activity BH3 domain binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process BH domain binding MDM2/MDM4 family protein binding
          It has to be done as per old AB suggested Products section.
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          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

          Learn more
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          We're here to help

          Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

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