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Invitrogen
Bestrophin 1 Polyclonal Antibody
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产品信息
PA1-31211
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, corresponding to amino acids 595-614 of Human Bestrophin.
偶联物
形式
Liquid
浓度
0.75 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
PA1-31211 detects Bestrophin from non-human primate, human samples.
PA1-31211 has been successfully used in immunocytochemistry, immunohistochemistry, Western blot, immunoprecipitation applications.
The PA1-31211 immunogen is: Synthetic peptide, corresponding to amino acids 595-614 of Human Bestrophin.
靶标信息
The retinal pigment epithelium (RPE) and choroid represent a differentiated system of the eye that sustains normal retinal health and function. Best vitelliform macular dystrophy, known as Best disease, is an early-onset autosomal dominant condition in which accumulation of lipofuscin-like material within and beneath the RPE leads to progressive loss of central vision. The lipofuscin-like material in the macular area appears as a yellow mass like the yolk of an egg that later becomes darker and irregular in color, a process known as "scrambling the egg". Best disease is frequently a reflection of mutations in the Bestrophin gene, which encodes a protein containing four putative transmembrane domains and localizes to the basolateral plasma membrane of RPE cells. Human Bestrophin forms oligomeric chloride channels that are sensitive to intracellular calcium. Missense mutations at the Bestrophin locus reduces or abolishes Bestrophin protein mediated membrane current. The human Bestrophin gene encodes a 585 amino acid protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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