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Invitrogen
Blood Group H Antigen Monoclonal Antibody (97-I)
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产品信息
MA1-7675
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgM
分类
Monoclonal
类型
Antibody
克隆号
97-I
抗原
H human blood protein.
偶联物
形式
Liquid
浓度
1 mg/mL
保存液
PBS, pH 7.2
内含物
0.01% sodium azide
保存条件
4°C short term, -80°C long term
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA17675 is an anti-H INH blood antigen antibody that can be used to detect the the H H antigen of red blood cells and body fluids. It can be used for the testing of I-antigen in blood, blood stains, saliva, and for spot analysis in forensic medicine by absorption-elution, ELISA, and Inhibition assays.
靶标信息
The H antigen is a precursor to the ABO blood group antigens, present in people of all common blood types. The Bombay phenotype (hh) does not express antigen H on red blood cells, and therefore this type will also lack A or B antigens, similar to the O blood group. However, unlike O group, the H antigen is absent, hence the individuals produce isoantibodies to antigen H as well as to both A and B antigens. If they receive blood from someone with O blood group, the anti-H antibodies will bind to the H antigen on the red blood cells of the donor blood and destroy the RBCs by complement-mediated lysis. Therefore, people with Bombay phenotype can receive blood only from other hh donors, although they can donate as though they were type O. Some individuals with the blood group A1 may also be able to produce anti-H antibodies due to the complete conversion of all the H antigen to A1 antigen. Production of the H antigen, or its deficiency in the Bombay phenotype, is controlled at the H locus on chromosome 19. The H locus contains three exons that span more than 5 kb of genomic DNA, and encodes the fucosyltransferase that produces the H antigen on RBCs. The H antigen is a carbohydrate sequence with carbohydrates linked mainly to protein (with a minor fraction attached to ceramide moiety).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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