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Proteintech
BubR1 Polyclonal Antibody, CoraLite® Plus 488
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产品信息
CL488-11504
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BubR1 fusion protein Ag2053
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: QSPWCSQYR RQLLKSLPEL SASAELCIED RPMPKLEIEK EIELGNEDYC IKREYLICED YKLFWVAPRN SAELTVIKVS SQPVPWDFYI NLKLKERLNE DFDHFCSCYQ YQDGCIVWHQ YINCFTLQDL LQHSEYITHE ITVLIIYNLL TIVEMLHKAE IVHGDLSPRC LILRNRIHDP YDCNKNNQAL KIVDFSYSVD LRVQLDVFTL SGFRTVQILE GQKILANCSS PYQVDLFGIA DLAHLLLFKE HLQVFWDGSF WKLSQNISEL KDGELWNKFF VRILNANDEA TVSVLGELAA EMNGVFDTTF QSHLNKALWK VGKLTSPGAL LFQ
靶标信息
BUBR1 is a member of the Ser/Thr protein kinase family. It is a component of the mitotic checkpoint that delays anaphase until all chromosome are properly attached to the mitotic spindle. Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BUB1B, mitotic checkpoint serine/threonine kinase; BubR1; budding uninhibited by benzimidazoles 1 beta; budding uninhibited by benzimidazoles 1 homolog beta; hBub1; hBUBR1; MAD3/BUB1-related protein kinase; Mitotic checkpoint kinase MAD3L; Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; Protein SSK1
基因别名: AU045529; Bub1A; BUB1B; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1
UniProt ID: (Human) O60566, (Mouse) Q9Z1S0
Entrez Gene ID: (Human) 701, (Mouse) 12236
protein phosphorylation
apoptotic process
sister chromatid cohesion
mitotic nuclear division
metaphase/anaphase transition of mitotic cell cycle
mitotic cell cycle checkpoint
mitotic spindle assembly checkpoint
cell proliferation
anaphase-promoting complex-dependent catabolic process
protein localization to kinetochore
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
cell cycle
phosphorylation
protein localization to chromosome, centromeric region
