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Invitrogen
C/EBP alpha Recombinant Rabbit Monoclonal Antibody (HL1747)
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C/EBP alpha Antibody (MA5-47166) in WB
Western blot analysis of C/EBP alpha in Various whole cell extracts (30 µg) separated by 10% SDS-PAGE. Membrane was blotted with C/EBP alpha Monoclonal antibody (Product # MA5-47166) using a dilution of 1:1,000 followed by HRP-conjugated anti-rabbit IgG secondary antibody. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-47166
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1747
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human C/EBP alpha. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP. One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation. From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C EBP; C/EBP alpha; CAAT/enhancer-binding protein, DNA-binding protein; CCAAT/enhancer binding protein (C/EBP), alpha; OTTHUMP00000220269
基因别名: C/EBP-alpha; CEBP; DBPCEP
UniProt ID: (Human) P49715, (Rat) P05554
Entrez Gene ID: (Human) 1050, (Rat) 24252
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase I regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
kinase binding
chromatin DNA binding
identical protein binding
protein homodimerization activity
sequence-specific DNA binding
protein heterodimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
HMG box domain binding
STAT family protein binding
DNA-binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
liver development
generation of precursor metabolites and energy
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase I promoter
negative regulation of cell proliferation
positive regulation of gene expression
cytokine-mediated signaling pathway
myeloid cell differentiation
lung development
granulocyte differentiation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
glucose homeostasis
positive regulation of macrophage activation
fat cell differentiation
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of inflammatory response
regulation of cell cycle
lipid homeostasis
interleukin-6-mediated signaling pathway
white fat cell proliferation
energy homeostasis
integrated stress response signaling
positive regulation of DNA-templated transcription, initiation
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