Invitrogen

C/EBP alpha Recombinant Rabbit Monoclonal Antibody (K01_4N24)

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问题与答案

问题与答案

问题与答案

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抗体检测数据 (1)

C/EBP alpha Antibody in Western Blot (WB)

C/EBP alpha Antibody in Western Blot (WB)

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C/EBP alpha Antibody (MA567447) in WB

Western Blot analysis of C/EBP alpha in U937 lysates using C/EBP alpha Recombinant Monoclonal Antibody (Product # MA567447).

C/EBP alpha Antibody in Western Blot (WB)

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C/EBP alpha Antibody in Western Blot (WB) — Western Blot analysis of C/EBP alpha in U937 lysates using C/EBP alpha Recombinant Monoclonal Antibody (Product # MA567447).

产品信息

MA567447

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

K01_4N24

抗原

A synthesized peptide derived from human CEBP alpha.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 50% glycerol, 150mM NaCl, 0.05% BSA

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP. One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation. From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: C EBP; C/EBP alpha; CAAT/enhancer-binding protein DNA-binding protein; CAAT/enhancer-binding protein, DNA-binding protein; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer binding protein, alpha; CCAAT/enhancer-binding protein alpha; OTTHUMP00000220269

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基因别名: C/EBP-alpha; C/ebpalpha; CBF-A; CEBP; CEBPA; DBPCEP

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UniProt ID: (Human) P49715, (Mouse) P53566, (Rat) P05554

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Entrez Gene ID: (Human) 1050, (Mouse) 12606, (Rat) 24252

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transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase I regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding kinase binding protein domain specific binding chromatin DNA binding identical protein binding protein homodimerization activity histone deacetylase binding sequence-specific DNA binding macromolecular complex binding protein heterodimerization activity RNA polymerase II sequence-specific DNA binding transcription factor binding HMG box domain binding STAT family protein binding DNA-binding transcription factor binding RNA polymerase I regulatory region DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity transcription factor binding protein complex binding transcription regulatory region DNA binding basic leucine zipper transcription factor

urea cycle negative regulation of transcription from RNA polymerase II promoter liver development embryonic placenta development epithelial cell maturation osteoblast development generation of precursor metabolites and energy transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase I promoter acute-phase response mitochondrion organization Notch signaling pathway response to nutrient memory cholesterol metabolic process cell proliferation negative regulation of cell proliferation positive regulation of gene expression cytokine-mediated signaling pathway myeloid cell differentiation cell differentiation macrophage differentiation lung development granulocyte differentiation organ regeneration positive regulation of proteasomal ubiquitin-dependent protein catabolic process response to vitamin B2 regulation of cell proliferation glucose homeostasis positive regulation of macrophage activation fat cell differentiation positive regulation of fat cell differentiation positive regulation of osteoblast differentiation negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter inner ear development positive regulation of inflammatory response white fat cell differentiation brown fat cell differentiation regulation of cell cycle lipid homeostasis interleukin-6-mediated signaling pathway white fat cell proliferation cellular response to lithium ion cellular response to tumor necrosis factor hematopoietic stem cell proliferation cellular response to xenobiotic stimulus response to dexamethasone response to phenylpropanoid energy homeostasis integrated stress response signaling negative regulation of hematopoietic stem cell proliferation positive regulation of DNA-templated transcription, initiation transcription from RNA polymerase II promoter multicellular organism development positive regulation of transcription from RNA polymerase III promoter cell maturation cellular response to organic cyclic compound response to glucocorticoid