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Proteintech
C11orf54 Polyclonal Antibody
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产品信息
23251-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
C11orf54 Fusion Protein Ag19731 (1-310 aa encoded by BC007110)
偶联物
形式
Liquid
浓度
0.31 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: RSGLWVFCY RDRLVMQKGL KDNFADVQVS VVDCPDLTKE PFTFPVKGIC GKTRIAEVGG VPYLLPLVNQ KKVYDLNKIA KEIKLPGAFI LGAGAGPFQT LGFNSEFMPV IQTESEHKPP VNGSYFAHVN PADGGCLLEK YSEKCHDFQC ALLANLFASE GQPGKVIEVK AKRRTGPLNF VTCMRETLEK HYGNKPIGMG GTFIIQKGKV KSHIMPAEFS SCPLNSDEEV NKWLHFYEMK APLVCLPVFV SRDPGFDLRL EHTHFFSRHG EGGHYHYDTT PDIVEYLGYF LPAEFLYRID QPKETHSIGR D (1-310 aa encoded by BC007110)
靶标信息
C11orf54, also known as Chromosome 11 Open Reading Frame 54, is an ester hydrolase highly conserved across various species. Located on chromosome 11, the gene is identified as a biomarker associated with renal cancers, although its precise biological function is not fully elucidated. Research has shown that C11orf54 plays a role in DNA repair mechanisms, particularly by blocking chaperone-mediated autophagy (CMA). Silencing this gene reduces cellular proliferation and heightens DNA damage and apoptosis when cells are treated with cisplatin, a common chemotherapeutic agent. This suggests C11orf54's involvement in cancer pathology, particularly its potential impact on DNA repair pathways, thereby supporting cell survival post DNA damage.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Ester hydrolase C11orf54; Ester hydrolase C11orf54 homolog
基因别名: C11orf54; LP4947; PTD012; PTOD012
UniProt ID: (Human) Q9H0W9, (Rat) Q5U2Q3
Entrez Gene ID: (Human) 28970, (Rat) 363016
