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OriGene
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RHNO1 plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: RAD9, HUS1, RAD1-interacting nuclear orphan protein 1; Rad9, Rad1, Hus1 interacting nuclear orphan; RAD9, RAD1, HUS1-interacting nuclear orphan protein
基因别名: C12orf32; HKMT1188; RHINO; RHNO1
UniProt ID: (Human) Q9BSD3
Entrez Gene ID: (Human) 83695