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Bioss
C17orf87 Polyclonal Antibody
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产品信息
BS-13685R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human C17orf87, amino acids 1-100.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DTFT5783; SLP adapter and CSK-interacting membrane protein; SLP adaptor and CSK interacting membrane protein; SLP65/SLP76, Csk-interacting membrane protein; transmembrane protein C17orf87; transmembrane protein C17orf87 homolog
基因别名: A430084P05Rik; C17orf87; SCIMP; UNQ5783; UNQ5783/PRO16090
UniProt ID: (Human) Q6UWF3, (Mouse) Q3UU41
Entrez Gene ID: (Human) 388325, (Mouse) 327957, (Rat) 691993
