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Proteintech
C1orf51 Polyclonal Antibody
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产品信息
21098-1-AP
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
C1orf51 Fusion Protein Ag15364 (1-385 aa encoded by BC027999)
偶联物
形式
Liquid
浓度
0.31 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MDSPSSVSS YSSYSLSSSF PTSPVNSDFG FPSDSEREDK GAHGPRPDTV GQRGGSRPSP GPIRCRHRSK VSGNQHTPSH PKQRGSASPM AGSGAKRSRD GELETSLNTQ GCTTEGDLLF AQKCKELQGF IPPLTDLLNG LKMGRFERGL SSFQQSVAMD RIQRIVGVLQ KPQMGERYLG TLLQVEGMLK TWFPQIAAQK SSLGGGKHQL TKHFPSHHSD SAASSPASPM EKMDQTQLGH LALKPKQPWH LTQWPAMNLT WIHTTPICNP PLSSPGTISF SHGPLGTGTG IGVILFLQHG VQPFTHSAPT TPVPPTTASP VIPGEPMKLS GEGPRCYSLP VTLPSDWSYT LSPPSLPTLA RKMTIGHREQ QRSHPPVAAD AHLLNL (1-385 aa encoded by B C027999)
靶标信息
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ChIP-derived repressor of network oscillator; Chrono; Circadian-associated transcriptional repressor; Computationally highlighted repressor of the network oscillator
基因别名: C1orf51; CHRONO; CIART; GM129
UniProt ID: (Human) Q8N365
Entrez Gene ID: (Human) 148523
