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Progen
C3a Monoclonal Antibody (H13)
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产品信息
61018PROGEN
应用
建议稀释比
已发表文章
产品规格
种属反应
Guinea pig,
Human,
Rabbit
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
H13
抗原
Human Complement Component C3
偶联物
形式
Lyophilized
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 0.5% BSA
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute lyophilized product with 1 mL distilled water.
H 13 recognizes a C3a-determinant (eg C3 alpha-chain) which is present also on native C3. H 13 allows discrimination of ubiquitous or nonspecifically bound native C3 from biologically active C3b fragment; C3b or C are negative with H 13 Polypeptide reacting: C3a-determinant on C3 alpha-chain Specific Application: Detection of C3 deposits in tissue, cells, microorganisms and immune complexes. It should be used with positive control anti-C3b (H11/H206). Non-activated, absorbed C3 contains the C3a determinant, whereas activated C3 is negative with H 13. This antibody was used in a Indirect ELISA.
靶标信息
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acylation-stimulating protein cleavage product; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3a anaphylatoxin; C3r1; Complement C3; complement C3 protein (GPC3) precursor; complement component 3; complement component C3 alpha-chain; complement component C3a; complement component C3b; epididymis secretory sperm binding protein Li 62p; prepro-C3
基因别名: AHUS5; ARMD9; ASP; C3; C3a; C3b; CPAMD1; HEL-S-62p
UniProt ID: (Guinea pig) P12387, (Human) P01024
Entrez Gene ID: (Guinea pig) 100135462, (Rabbit) 100009121, (Human) 718
positive regulation of type IIa hypersensitivity
positive regulation of protein phosphorylation
positive regulation of activation of membrane attack complex
tolerance induction
proteolysis
fatty acid metabolic process
inflammatory response
immune response
complement activation
complement activation, alternative pathway
complement activation, classical pathway
signal transduction
G-protein coupled receptor signaling pathway
blood coagulation
positive regulation of vascular endothelial growth factor production
positive regulation of glucose transport
regulation of triglyceride biosynthetic process
positive regulation of lipid storage
negative regulation of endopeptidase activity
regulation of complement activation
response to magnesium ion
response to estradiol
response to progesterone
response to estrogen
positive regulation of G-protein coupled receptor protein signaling pathway
positive regulation of angiogenesis
positive regulation of developmental growth
regulation of immune response
response to glucocorticoid
positive regulation of ERK1 and ERK2 cascade
positive regulation of apoptotic cell clearance
