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Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf225 gene product has been provisionally designated C6orf225 pending further characterization.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: family with sequence similarity 229, member B; Protein FAM229B; UPF0731 protein C6orf225; UPF0731 protein C6orf225 homolog
基因别名: 1700025K23Rik; C6orf225; FAM229B
UniProt ID: (Human) Q4G0N7, (Mouse) Q8CF36, (Rat) B0BND4
Entrez Gene ID: (Human) 619208, (Mouse) 66337, (Rat) 100188933