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产品信息
PA5-56871
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human C6orf57
偶联物
Unconjugated
形式
Liquid
浓度
0.10 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2639121
产品详细信息
Immunogen sequence: SPLLCHSLRK TSSSQGGKSE LVKQSLKKPK LPEGRFDAPE DSHLEKEPLE KFPDDVNPVT KEKGGPRGPE PTRYGDWERK GRCID
Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 78%.
靶标信息
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit Sdha in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit Sdhb into the SDH catalytic dimer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: SDH assembly factor 4; Succinate dehydrogenase assembly factor 4, mitochondrial; UPF0369 protein C6orf57
基因别名: C6orf57; Sdh8; SDHAF4
UniProt ID: (Human) Q5VUM1
Entrez Gene ID: (Human) 135154
分子生物学功能:
chaperone
