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Proteintech
CARD14 Polyclonal Antibody
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产品信息
10400-1-AP
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CARD14 Fusion Protein Ag0628 (1-300 aa encoded by BC018142)
偶联物
形式
Liquid
浓度
0.29 mg/mL
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MGELCRRDS ALTALDEETL WEMMESHRHR IVRCICPSRL TPYLRQAKVL CQLDEEEVLH SPRLTNSAMR AGHLLDLLKT RGKNGAIAFL ESLKFHNPDV YTLVTGLQPD VDFSNFSGLM ETSKLTECLA GAIGSLQEEL NQEKGQKEVL LRRCQQLQEH LGLAETRAEG LHQLEADHSR MKREVSAHFH EVLRLKDEML SLSLHYSNAL QEKELAASRC RSLQEELYLL KQELQRANMV SSCELELQEQ SLRTASDQES GDEELNRLKE ENEKLRSLTF SLAEKDILEQ SLDEARGSRQ E (1-300 aa encoded by BC018142)
靶标信息
Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3) and the caspase-associated recruitment domain (CARD) proteins: CARD 6, CARD 8-12 and CARD 14. CARD 14 is a 1,004 amino acid protein consisting of an N-terminal CARD domain, a central coiled-coil domain and a C-terminal tripartite domain comprised of a PDZ domain, an Src homology 3 domain and a GUK domain with homology to guanylate kinase. CARD 14 is expressed in the placenta where it positively regulates apoptosis. CARD 14 also controls NF-kappaB activation by phosphorylating BCL10, a signaling protein that activates NF-kappaB through the I kappaB kinase complex. Epigallocatechin-3-gallate (EGCG) is a polyphenol that induces the expression of CARD 14.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
