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Proteintech
CATSPER1 Polyclonal Antibody
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产品信息
12722-1-AP
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CATSPER1 fusion protein Ag3417
偶联物
形式
Liquid
浓度
0.7 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: MDQNSVPEKA QNEADTNNAD RFFRSHSSPP HHRPGHSRAL HHYELHHHGV PHQRGESHHP PEFQDFHDQA LSSHVHQSHH HSEARNHVRA HGPTGFGLAP SQGAVPSHRS YGEDYHDELQ RDGRRHHDGS QYSGFHQQSD SHYHRGSHHG RPQYLGENLS HYSSGVPHHG EASHHGGSYL PHGPNPYSES FHHSEASHLS GLQHDESQHH QVPHRGWPHH HQVHHHGRSR HHEAHQHGKS PHHGETISPH SSVGSYQRGI SDYHSEYHQG DHHPSEYHHG DHPHHTQHHY HQTHRHRDYH QH
靶标信息
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cation channel sperm-associated protein 1; cation channel, sperm associated 1; CatSper1; hCatSper; sperm ion channel; sperm-associated cation channel 1
基因别名: CATSPER; CATSPER1; SPGF7
UniProt ID: (Human) Q8NEC5
Entrez Gene ID: (Human) 117144
multicellular organism development
spermatogenesis
fusion of sperm to egg plasma membrane
cell differentiation
sperm motility
response to progesterone
regulation of ion transmembrane transport
sperm-egg recognition
regulation of calcium ion transport
regulation of cilium beat frequency involved in ciliary motility
calcium ion transmembrane transport
membrane depolarization during action potential
