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产品信息
PA5-50372
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化（石蜡） (IHC (P)) |
1:25-1:100 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Fusion protein corresponding to residues near the C terminal of human cation channel, sperm associated 1 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1.8 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 40% glycerol |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2635825 |
产品详细信息
The antibody detects endogenous levels of total CATSPER1 protein.
靶标信息
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cation channel sperm-associated protein 1; cation channel, sperm associated 1; CatSper1; hCatSper; sperm ion channel; sperm-associated cation channel 1
基因别名: CATSPER; CATSPER1; SPGF7
UniProt ID: (Human) Q8NEC5
Entrez Gene ID: (Human) 117144
分子生物学功能:
ion channel
transporter
multicellular organism development
spermatogenesis
fusion of sperm to egg plasma membrane
cell differentiation
sperm motility
response to progesterone
regulation of ion transmembrane transport
sperm-egg recognition
regulation of calcium ion transport
regulation of cilium beat frequency involved in ciliary motility
calcium ion transmembrane transport
membrane depolarization during action potential
