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Invitrogen
CATSPER3 Polyclonal Antibody
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CATSPER3 Antibody (PA5-103716) in ICC/IF
Immunofluorescent analysis of CATSPER3 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and CATSPER3 polyclonal antibody (Product # PA5-103716) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-103716
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CATSPER3(Accession Q86XQ3), corresponding to amino acid residues L183-Q233.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total CATSPER3.
靶标信息
CatSpers (cation channel, sperm associated proteins) are ion transport proteins located on the surface of sperm cells in the principal piece of the sperm tail. CatSpers are vital to sperm motility, fertilization and cAMP-mediated calcium influx in sperm. There are four CatSper proteins in mammalian sperm, namely CatSper (or CatSper1), CatSper2, CatSper3 and CatSper4. CatSper proteins contain a single, six-transmembrane-spanning segment and exhibit the voltage-dependent Ca2+ channel four-repeat structure. CatSper proteins are believed to assemble into a heterotetrameric complex, forming an alkalinization-activated Ca2+-selective channel. Mutations in any of the genes encoding CatSper family proteins can result in male infertility. CatSper3 plays an important role in the hyperactivated motility of sperm cells, a process that is required in the preparation of sperm for fertilization.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ca(v)-like protein; calcium channel repeat containing 1; Cation channel sperm-associated protein 3; cation channel, sperm associated 3; CatSper3; One-repeat calcium channel-like protein; putative ion channel CatSper3
基因别名: 4921522D01Rik; CACRC; CATSPER3
UniProt ID: (Human) Q86XQ3, (Mouse) Q80W99
Entrez Gene ID: (Human) 347732, (Mouse) 76856
sodium ion transport
calcium ion transport
multicellular organism development
sperm motility
response to progesterone
ion transmembrane transport
regulation of ion transmembrane transport
sperm-egg recognition
sperm capacitation
calcium ion transmembrane transport
membrane depolarization during action potential
transport
ion transport
spermatogenesis
cell differentiation
transmembrane transport
calcium ion import
