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Bethyl Laboratories
CBF-beta (isoform 2) Polyclonal Antibody
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CBF-beta (isoform 2) Antibody (A303-548A) in WB
Detection of Isoform 2 of human CBF-beta by western blot and immunoprecipitation. Samples: Whole cell lysate from Jurkat (15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded), HEK293T (T; 50 µg) and HeLa (H; 50 µg) cells. Antibodies: Affinity purified rabbit anti-CBF-beta (isoform 2) antibody (Product # A303-548A) used for WB at 0.4 µg/mL (A) and 1 µg/mL (B) and used for IP at 6 µg/mg lysate. Isoform 2 of CB... View More
产品信息
A303-548A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 166 and 182 of human Core-Binding Factor, Beta Subunit.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
phosphate/tris citrate, pH 7-8
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
CBFB is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CBF-beta; Core-binding factor subunit beta; PEA2-beta; PEBP2-beta; polyomavirus enhancer binding protein 2, beta subunit; Polyomavirus enhancer-binding protein 2 beta subunit; SL3-3 enhancer factor 1 beta subunit; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit
基因别名: CBFB; PEBP2B
UniProt ID: (Human) Q13951
Entrez Gene ID: (Human) 865
protein polyubiquitination
osteoblast differentiation
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
lymphocyte differentiation
myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
cell maturation
definitive hemopoiesis
