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Invitrogen
CCDC105 Polyclonal Antibody
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产品信息
PA5-63588
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: RDTLNFCFKE RLQAVDLMNQ PLDKVLEQAR RHSWVNLSRA PTPRTQGQKT PPPDPVGTYN PACALALNEA KR
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 79%.
靶标信息
CCDC105 (Coiled-Coil Domain-Containing 105) is a gene that encodes a protein involved in various cellular processes, primarily associated with the structure and function of centrioles and cilia. The CCDC105 protein contains coiled-coil domains that facilitate protein-protein interactions, crucial for the assembly and stabilization of microtubule structures within cells. Studies indicate that CCDC105 plays a key role in ciliogenesis, the process by which cells form cilia, which are essential for cell motility, fluid movement, and signal transduction. Dysregulation or mutations in CCDC105 have been implicated in ciliopathies, a group of disorders arising from defective cilia, leading to symptoms such as respiratory issues, kidney disease, and developmental abnormalities. Research continues to explore the specific molecular mechanisms by which CCDC105 influences ciliary dynamics and its broader implications in human health and disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Coiled-coil domain-containing protein 105; Tektin-like protein 1
基因别名: CCDC105; TEKTL1
UniProt ID: (Human) Q8IYK2
Entrez Gene ID: (Human) 126402
