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Proteintech
CCDC88C Polyclonal Antibody
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产品信息
25769-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CCDC88C Fusion Protein Ag22711 (1-371 aa encoded by BC028565)
偶联物
形式
Liquid
浓度
0.27 mg/mL
规格
40.5 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: VRPCSASPS SEMVTLEEFL EESNRSSPTH DTPSCRDDLL SDYFRKASDP PAIGGQPGPP AKKEGAKMPT NFVAPTVKMA APTSEGRPLK PGQYVKPNFR LTEAEAPPSV APRQAQPPQS LSLGRPRQAP VPPASHAPAS RSASLSRAFS LASADLLRAS GPEACKQESP QKLGAPEALG GRETGSHTLQ SPAPPSSHSL ARERTPLVGK AGSSCQGPGP RSRPLDTRRF SLAPPKEERL APLHQSATAP AIATAGAGAA AAGSGSNSQL LHFSPAAAPA ARTKPKAPPR SGEVATITPV RAGLSLSEGD GVPGQGCSEG LPAKSPGRSP DLAPHPGRAL EDCSRGSVSK SSPASPEPGG DPQTVWYEYG CV (1-371 aa encoded by BC028565)
靶标信息
This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the disheveled protein and is a negative regulator of the Wnt signaling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the disheveled protein. Disheveled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Coiled-coil domain-containing protein 88C; Dvl-associating protein with a high frequency of leucine residues; hDaple; HkRP2; Hook-related protein 2; Protein Daple; spinocerebellar ataxia 40; unnamed protein product
基因别名: CCDC88C; DAPLE; HKRP2; HYC1; KIAA1509; SCA40
UniProt ID: (Human) Q9P219
Entrez Gene ID: (Human) 440193
microtubule bundle formation
cilium movement
apical constriction
negative regulation of microtubule depolymerization
signal transduction
small GTPase mediated signal transduction
Wnt signaling pathway
cytoskeleton-dependent intracellular transport
cytoplasmic microtubule organization
protein destabilization
non-canonical Wnt signaling pathway
cilium organization
positive regulation of JNK cascade
Wnt signaling pathway, planar cell polarity pathway
negative regulation of canonical Wnt signaling pathway
mucociliary clearance
respiratory basal cell differentiation
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