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CCL21 Antibody (711339) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of MCF7 (Lane 1), T-47D (Lane 2), MDA-MB-231 (Lane 3), Caco-2 (Lane 4), HCT 116 (Lane 5), SW480 (Lane 6) and HT-29 (Lane 7). The blots were probed with Anti-CCL21 Recombinant Rabbit Polyclonal Antibody (Product # 711339, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). A 15 kDa band corresponding to CCL21 was observed across cell lines t... View More
产品信息
711339
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
6HCLC
抗原
Protein corresponding to Human CCL21 (aa 24-134)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2633163
产品详细信息
This antibody is predicted to react with Monkey, Cat, Pig and Bovine.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 6 Ckine; 6Ckine; beta chemokine exodus-2; Beta-chemokine exodus-2; C-C motif chemokine 21; chemokine (C-C motif) ligand 21; Efficient Chemoattractant for Lymphocytes; secondary lymphoid tissue chemokine; Secondary lymphoid-tissue chemokine; SLC; small inducible cytokine subfamily A (Cys-Cys), member 21; Small-inducible cytokine A21
基因别名: 6Ckine; CCL21; CKb9; ECL; SCYA21; SLC; TCA4; UNQ784/PRO1600
UniProt ID: (Human) O00585
Entrez Gene ID: (Human) 6366
establishment of T cell polarity
immunological synapse formation
positive regulation of cell-matrix adhesion
dendritic cell chemotaxis
monocyte chemotaxis
positive regulation of dendritic cell antigen processing and presentation
inflammatory response
immune response
G-protein coupled receptor signaling pathway
cell-cell signaling
positive regulation of glycoprotein biosynthetic process
positive regulation of actin filament polymerization
positive regulation of pseudopodium assembly
T cell costimulation
ruffle organization
positive regulation of cell adhesion mediated by integrin
response to prostaglandin E
mesangial cell-matrix adhesion
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of protein kinase activity
positive regulation of JNK cascade
lymphocyte chemotaxis
positive regulation of receptor-mediated endocytosis
cell maturation
positive regulation of chemotaxis
release of sequestered calcium ion into cytosol
positive regulation of filopodium assembly
positive regulation of protein kinase B signaling
cell chemotaxis
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
positive regulation of neutrophil chemotaxis
activation of GTPase activity
dendritic cell dendrite assembly
negative regulation of leukocyte tethering or rolling
negative regulation of leukocyte apoptotic process
positive regulation of cell motility
positive regulation of T cell migration
positive regulation of myeloid dendritic cell chemotaxis
negative regulation of dendritic cell dendrite assembly
