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CCNK Antibody (PA5-114710) in ICC/IF
Immunocytochemistry analysis of CCNK in A549 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-114710). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
产品信息
PA5-114710
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CCNK(Accession O75909), corresponding to amino acid residues M1-L38.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2899346
产品详细信息
Antibody detects endogenous levels of total CCNK.
靶标信息
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cyclin-K
基因别名: AW123198; AW413594; CCNK; CPR4; CycK
UniProt ID: (Human) O75909
Entrez Gene ID: (Human) 8812, (Mouse) 12454
regulation of cyclin-dependent protein serine/threonine kinase activity
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
protein phosphorylation
cellular response to DNA damage stimulus
mitotic nuclear division
snRNA transcription from RNA polymerase II promoter
negative regulation by host of viral genome replication
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transcription from RNA polymerase II promoter
cell division
negative regulation of cell cycle arrest
positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues
in utero embryonic development
transcription, DNA-templated
regulation of transcription, DNA-templated
cell cycle
