Invitrogen

CCR1 Recombinant Superclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

查看其他19个CCR1抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

抗体检测数据 (1)
高级验证 (1)

CCR1 Antibody in Immunocytochemistry (ICC/IF)

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CCR1 Antibody (711250) in ICC/IF

For immunofluorescence analysis, RAMOS cells were fixed and permeabilized for detection of endogenous CCR1 using Anti-CCR1 Recombinant Rabbit Polyclonal Antibody (Product # 711250, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of CCR1 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938).... View More

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Antibody specificity was demonstrated by detection of differential basal expression of the target across two cell models owing to their inherent genetic constitution. Expression of CCR1 was observed specifically in Ramos cell line using CCR1 Antibody (1HCLC) Recombinant Rabbit Polyclonal (Product # 711250) in immunofluorescence analysis as compared to HEK-293 cell line. {RE}

产品信息

711250

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

Expi293

分类

Recombinant Superclonal

类型

Antibody

抗原

Peptides corresponding to Human CCR1(aa 15-30, 224-237)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2633141

产品详细信息

This antibody is predicted to react with Monkey, Bovine and Sheep

Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.

靶标信息

Chemokines play important roles in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CD191; chemokine (C-C motif) receptor 1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES receptor; RANTES-R

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基因别名: CCR1; CD191; CKR-1; CKR1; CMKBR1; CMKR1; HM145; MIP1aR; SCYAR1

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UniProt ID: (Human) P32246

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Entrez Gene ID: (Human) 1230

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功能

phosphatidylinositol phospholipase C activity chemokine receptor activity protein binding C-C chemokine receptor activity C-C chemokine binding chemokine (C-C motif) ligand 7 binding chemokine (C-C motif) ligand 5 binding

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