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Invitrogen
CCR7 Polyclonal Antibody
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产品信息
PA5-33401
应用
建议稀释比
已发表文章
产品规格
种属反应
Bat,
Bovine,
Horse,
Human,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 17 amino acid peptide from C-terminus of human CCR7.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bat, Bovine, Horse (100%) Mouse, Rat, Hamster, Elephant, Panda, Dog, Rabbit, Pig (94%).
靶标信息
CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naive from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC's. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BLR2; Bukitt's lymphoma receptor 2; C-C chemokine receptor type 7; C-C CKR-7; C-C motif; CC chemokine receptor 7; CC-CKR-7; CCR-7; CD197; CDw197; chemokine (C-C motif) receptor 7; EBI1; EBV-induced G protein-coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus-induced G-protein coupled receptor 1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor
基因别名: BLR2; CC-CKR-7; CCR-7; CCR7; CD197; CDw197; CMKBR7; EBI1; EVI1
UniProt ID: (Human) P32248
Entrez Gene ID: (Human) 1236, (Bovine) 510668, (Horse) 100067673
establishment of T cell polarity
positive regulation of cell-matrix adhesion
dendritic cell chemotaxis
myeloid dendritic cell chemotaxis
positive regulation of dendritic cell antigen processing and presentation
positive regulation of hypersensitivity
positive regulation of humoral immune response
inflammatory response
immune response
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
positive regulation of actin filament polymerization
positive regulation of pseudopodium assembly
ruffle organization
response to lipopolysaccharide
regulation of interferon-gamma production
positive regulation of interleukin-12 production
response to prostaglandin E
chemokine (C-C motif) ligand 19 signaling pathway
chemokine (C-C motif) ligand 21 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of phosphatidylinositol 3-kinase activity
negative thymic T cell selection
positive regulation of cell adhesion
positive regulation of protein kinase activity
positive regulation of JNK cascade
homeostasis of number of cells
regulation of interleukin-1 beta secretion
positive regulation of T cell receptor signaling pathway
release of sequestered calcium ion into cytosol
positive regulation of filopodium assembly
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
cellular response to cytokine stimulus
response to nitric oxide
interleukin-12 secretion
positive regulation of neutrophil chemotaxis
activation of GTPase activity
lymphocyte migration into lymph node
mature conventional dendritic cell differentiation
negative regulation of leukocyte apoptotic process
positive regulation of cell motility
positive regulation of dendritic cell chemotaxis
positive regulation of immunological synapse formation
positive regulation of T cell costimulation
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
regulation of dendritic cell dendrite assembly
