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Invitrogen
CD105 Monoclonal Antibody (MEM-229), Alexa Fluor™ 488
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CD105 Antibody (MA562182) in Flow
Flow cytometry (surface staining) of CD105 in HUVEC cells. Samples were stained with CD105 monoclonal antibody (Product # MA562182) using a dilution of 0.56 µg/mL. Separation of stained HUVEC cells (red-filled) from HUVEC cells stained using mouse IgG1 isotype control (MOPC-21) Alexa Fluor® 488 antibody (0.56 µg/mL, black-dashed).
产品信息
MA562182
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Pig
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
MEM-229
抗原
Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
偶联物
激发/发射光谱
499/520 nm
查看光谱
形式
Liquid
浓度
0.105 mg/mL
纯化类型
Size-exclusion chromatography
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
15mM sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
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生物信息学
蛋白别名: CD105; CD105 antigen; Endoglin; ORW
基因别名: END; ENG; HHT1; ORW1
UniProt ID: (Human) P17813, (Pig) P37176
Entrez Gene ID: (Human) 2022, (Pig) 397096
transmembrane signaling receptor activity
transforming growth factor beta receptor, cytoplasmic mediator activity
type II transforming growth factor beta receptor binding
protein binding
galactose binding
glycosaminoglycan binding
type I transforming growth factor beta receptor binding
BMP binding
protein homodimerization activity
activin binding
transforming growth factor beta binding
transmembrane signal receptor
chronological cell aging
patterning of blood vessels
vasculogenesis
positive regulation of protein phosphorylation
heart looping
sprouting angiogenesis
endocardial cushion morphogenesis
cardiac ventricle morphogenesis
cardiac atrium morphogenesis
ventricular trabecula myocardium morphogenesis
cell migration involved in endocardial cushion formation
regulation of transcription, DNA-templated
cell adhesion
negative regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
regulation of transforming growth factor beta receptor signaling pathway
central nervous system vasculogenesis
negative regulation of cell migration
BMP signaling pathway
positive regulation of BMP signaling pathway
negative regulation of protein autophosphorylation
dorsal aorta morphogenesis
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
smooth muscle tissue development
artery morphogenesis
venous blood vessel morphogenesis
endocardial cushion to mesenchymal transition
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
transforming growth factor beta receptor signaling pathway
