Product References
Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment.
Cellular & molecular biology letters
Meng Y,Pospiech M,Ali A,Chandwani R,Vergel M,Onyemaechi S,Yaghmour G,Lu R,Alachkar H
48-0112-82 was used in Flow cytometry/Cell sorting to investigate whether targeting CD36 has any detrimental impact on normal hematopoietic cells.
Wed May 24 00:00:00 EDT 2023
Melatonin regulates microglial polarization to M2 cell via RhoA/ROCK signaling pathway in epilepsy.
Immunity, inflammation and disease
Li P,Ji X,Shan M,Wang Y,Dai X,Yin M,Liu Y,Guan L,Ye L,Cheng H
48-0112-82 was used in Flow cytometry/Cell sorting to find that melatonin had a significant protective effect in LPS-treated BV-2 cells and ROCK-KD cells, while the protective effect of melatonin was significantly attenuated in ROCK-OE cells.
Thu Jun 01 00:00:00 EDT 2023
Redox regulation of age-associated defects in generation and maintenance of T cell self-tolerance and immunity to foreign antigens.
Cell reports
Hester AK,Semwal MK,Cepeda S,Xiao Y,Rueda M,Wimberly K,Venables T,Dileepan T,Kraig E,Griffith AV
48-0112-82 was used in Flow Cytometry to find that diminished expression of a model tissue-restricted antigen gene in aged thymic stromal cells correlates with impaired clonal deletion of cognate T cells recognizing an autoantigen involved in atherosclerosis.
Tue Feb 15 00:00:00 EST 2022
Antibody-drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties.
Oncoimmunology
Sommer A,Berndt S,Lerchen HG,Forveille S,Sauvat A,Mumberg D,Kroemer G,Kepp O
48-0112-82 was used in Flow Cytometry to conclude that the antineoplastic effects of TWEAKR-KSPi-ADCs can partly be attributed to its ICD-stimulatory properties.
Fri Apr 08 00:00:00 EDT 2022
Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell-Mediated Antitumor Immune Responses.
Cancer immunology research
Fedoriw A,Shi L,O'Brien S,Smitheman KN,Wang Y,Hou J,Sherk C,Rajapurkar S,Laraio J,Williams LJ,Xu C,Han G,Feng Q,Bedford MT,Wang L,Barbash O,Kruger RG,Hwu P,Mohammad HP,Peng W
48-0112-82 was used in Flow cytometry/Cell sorting to indicate that type I PRMT inhibition exhibits immunomodulatory properties and synergizes with immune checkpoint blockade to induce durable antitumor responses in a T cell-dependent manner, suggesting that type I PRMT inhibition can potentiate an antitumor immunity in refractory settings.
Fri Apr 01 00:00:00 EDT 2022
Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis.
Nature communications
Zhao M,Shao F,Yu D,Zhang J,Liu Z,Ma J,Xia P,Wang S
48-0112-82 was used in Flow cytometry/Cell sorting to show that ILC2s undergo translocation via the lung-gut axis upon IL-33 treatment.
Fri Dec 09 00:00:00 EST 2022
Foxo3a tempers excessive glutaminolysis in activated T cells to prevent fatal gut inflammation in the murine IL-10-/- model of colitis.
Cell death and differentiation
Hajjar S,Nathan N,Joseph J,Mottawea W,Ariana A,Pyatibrat S,Harper ME,Alain T,Blais A,Russell RC,Sad S
48-0112-82 was used in Flow cytometry/Cell sorting to show that Foxo3a restricts the abundance of colitogenic microbiota in IL-10-deficient mice.
Tue Mar 01 00:00:00 EST 2022
Transcriptomic and Lipidomic Mapping of Macrophages in the Hub of Chronic Beta-Adrenergic-Stimulation Unravels Hypertrophy-, Proliferation-, and Lipid Metabolism-Related Genes as Novel Potential Markers of Early Hypertrophy or Heart Failure.
Biomedicines
Nadaud S,Flamant M,Le Goff W,Balse E,Pavoine C
48-0112-82 was used in Flow Cytometry to characterise the temporal transcriptomic evolution of cardiac macrophages in mice subjected to beta-adrenergic-stimulation using RNA sequencing.
Thu Jan 20 00:00:00 EST 2022
Evidence for oligodendrocyte progenitor cell heterogeneity in the adult mouse brain.
Scientific reports
Beiter RM,Rivet-Noor C,Merchak AR,Bai R,Johanson DM,Slogar E,Sol-Church K,Overall CC,Gaultier A
48-0112-82 was used in Flow cytometry/Cell sorting to investigate the exact mechanisms through which Oligodendrocyte progenitor cells might influence brain function.
Thu Jul 28 00:00:00 EDT 2022
NAD+ metabolism drives astrocyte proinflammatory reprogramming in central nervous system autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Meyer T,Shimon D,Youssef S,Yankovitz G,Tessler A,Chernobylsky T,Gaoni-Yogev A,Perelroizen R,Budick-Harmelin N,Steinman L,Mayo L
48-0112-82 was used in Flow cytometry/Cell sorting to identify candidate therapeutic targets in multiple sclerosis.
Tue Aug 30 00:00:00 EDT 2022
Impact of mouse model tumor implantation site on acquired resistance to anti-PD-1 immune checkpoint therapy.
Frontiers in immunology
Denis M,Mathé D,Micoud M,Choffour PA,Grasselly C,Matera EL,Dumontet C
48-0112-82 was used in flow cytometry to demonstrate several differences between SC and orthotopic models at basal state, which tend to become similar after therapy.
Tue Jan 31 00:00:00 EST 2023
Tumor-Microenvironment Characterization of the MB49 Non-Muscle-Invasive Bladder-Cancer Orthotopic Model towards New Therapeutic Strategies.
International journal of molecular sciences
Domingos-Pereira S,Sathiyanadan K,Polak L,Haefliger JA,Schmittnaegel M,Ries CH,Jichlinski P,Roth B,Derré L,Nardelli-Haefliger D
48-0112-82 was used in Flow cytometry/Cell sorting to show a 100-fold increase in CD45+ immune cells from day 5 to day 9 tumors including T cells and mainly myeloid cells.
Wed Dec 21 00:00:00 EST 2022
Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.
Cell metabolism
Mills EL,Harmon C,Jedrychowski MP,Xiao H,Gruszczyk AV,Bradshaw GA,Tran N,Garrity R,Laznik-Bogoslavski D,Szpyt J,Prendeville H,Lynch L,Murphy MP,Gygi SP,Spiegelman BM,Chouchani ET
48-0112-82 was used in Flow cytometry/Cell sorting to establish the UCP1 C253 activation site as a regulator of acute thermogenesis and sex-dependent tissue inflammation.
Tue Jan 04 00:00:00 EST 2022
Loss of T cell tolerance in the skin following immunopathology is linked to failed restoration of the dermal niche by recruited macrophages.
Cell reports
West HC,Davies J,Henderson S,Adegun OK,Ward S,Ferrer IR,Tye CA,Vallejo AF,Jardine L,Collin M,Polak ME,Bennett CL
48-0112-82 was used in Flow cytometry/Cell sorting to demonstrate that pathology initiates dermis-specific macrophage differentiation and show that aGVHD-primed macrophages continue to dominate the dermal compartment at the relative expense of quiescent MHCIIint cells.
Tue May 17 00:00:00 EDT 2022
The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function.
eLife
Li S,Bern MD,Miao B,Fan C,Xing X,Inoue T,Piersma SJ,Wang T,Colonna M,Kurosaki T,Yokoyama WM
48-0112-82 was used in Flow cytometry/Cell sorting to investigate the role of Bach2 in natural killer (NK) cell development, revealing that Bach2 expression peaked in immature CD27+CD11b+ cells, and its deficiency led to increased proportions of terminally differentiated NK cells with enhanced granzyme and cytokine production, as well as improved NK cell-mediated control of tumor metastasis.
Mon Oct 03 00:00:00 EDT 2022
Bladder Cancer Extracellular Vesicles Elicit a CD8 T Cell-Mediated Antitumor Immunity.
International journal of molecular sciences
Ortiz-Bonilla CJ,Uccello TP,Gerber SA,Lord EM,Messing EM,Lee YF
48-0112-82 was used in Flow cytometry/Cell sorting to support the potential application of TEVs in personalized medicine, and open new avenues for the development of adjuvant therapies based on patient-derived EVs aimed at preventing disease progression.
Tue Mar 08 00:00:00 EST 2022
Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development.
Cellular and molecular gastroenterology and hepatology
Serra M,Di Matteo M,Serneels J,Pal R,Cafarello ST,Lanza M,Sanchez-Martin C,Evert M,Castegna A,Calvisi DF,Mazzone M,Columbano A
48-0112-82 was used in Flow cytometry/Cell sorting to investigate whether lactate dehydrogenase-A genetic ablation interferes with metabolic reprogramming and hepatocellular carcinoma development in the mouse.
Mon Aug 29 00:00:00 EDT 2022
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes.
Cell
Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD
48-0112 was used in Flow cytometry/Cell sorting to show that only the combination of TNF-α and IFN-γ induced inflammatory cell death characterized by inflammatory cell death, PANoptosis while multiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection.
Thu Jan 07 00:00:00 EST 2021
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis.
Cell stem cell
Leimkühler NB,Gleitz HFE,Ronghui L,Snoeren IAM,Fuchs SNR,Nagai JS,Banjanin B,Lam KH,Vogl T,Kuppe C,Stalmann USA,Büsche G,Kreipe H,Gütgemann I,Krebs P,Banz Y,Boor P,Tai EW,Brümmendorf TH,Koschmieder S,Crysandt M,Bindels E,Kramann R,Costa IG,Schneider RK
48-0112-82 was used in Flow Cytometry to develop a comprehensive map of the stroma in myeloproliferative neoplasms (MPNs)on a single-cell level in murine models and patient samples.
Thu Apr 01 00:00:00 EDT 2021
The metalloproteinase ADAM10 requires its activity to sustain surface expression.
Cellular and molecular life sciences : CMLS
Seifert A,Düsterhöft S,Wozniak J,Koo CZ,Tomlinson MG,Nuti E,Rossello A,Cuffaro D,Yildiz D,Ludwig A
48-0112-82 was used in Flow Cytometry to demonstrate that loss of proteolytic activity of ADAM10 by either inhibition or loss of function mutations induces removal of the protease from the cell surface and the whole cell.
Fri Jan 01 00:00:00 EST 2021
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).
European journal of immunology
Cossarizza A,Chang HD,Radbruch A,Abrignani S,Addo R,Akdis M,Andrä I,Andreata F,Annunziato F,Arranz E,Bacher P,Bari S,Barnaba V,Barros-Martins J,Baumjohann D,Beccaria CG,Bernardo D,Boardman DA,Borger J,Böttcher C,Brockmann L,Burns M,Busch DH,Cameron G,Cammarata I,Cassotta A,Chang Y,Chirdo FG,Christakou E,Čičin-Šain L,Cook L,Corbett AJ,Cornelis R,Cosmi L,Davey MS,De Biasi S,De Simone G,Del Zotto G,Delacher M,Di Rosa F,Di Santo J,Diefenbach A,Dong J,Dörner T,Dress RJ,Dutertre CA,Eckle SBG,Eede P,Evrard M,Falk CS,Feuerer M,Fillatreau S,Fiz-Lopez A,Follo M,Foulds GA,Fröbel J,Gagliani N,Galletti G,Gangaev A,Garbi N,Garrote JA,Geginat J,Gherardin NA,Gibellini L,Ginhoux F,Godfrey DI,Gruarin P,Haftmann C,Hansmann L,Harpur CM,Hayday AC,Heine G,Hernández DC,Herrmann M,Hoelsken O,Huang Q,Huber S,Huber JE,Huehn J,Hundemer M,Hwang WYK,Iannacone M,Ivison SM,Jäck HM,Jani PK,Keller B,Kessler N,Ketelaars S,Knop L,Knopf J,Koay HF,Kobow K,Kriegsmann K,Kristyanto H,Krueger A,Kuehne JF,Kunze-Schumacher H,Kvistborg P,Kwok I,Latorre D,Lenz D,Levings MK,Lino AC,Liotta F,Long HM,Lugli E,MacDonald KN,Maggi L,Maini MK,Mair F,Manta C,Manz RA,Mashreghi MF,Mazzoni A,McCluskey J,Mei HE,Melchers F,Melzer S,Mielenz D,Monin L,Moretta L,Multhoff G,Muñoz LE,Muñoz-Ruiz M,Muscate F,Natalini A,Neumann K,Ng LG,Niedobitek A,Niemz J,Almeida LN,Notarbartolo S,Ostendorf L,Pallett LJ,Patel AA,Percin GI,Peruzzi G,Pinti M,Pockley AG,Pracht K,Prinz I,Pujol-Autonell I,Pulvirenti N,Quatrini L,Quinn KM,Radbruch H,Rhys H,Rodrigo MB,Romagnani C,Saggau C,Sakaguchi S,Sallusto F,Sanderink L,Sandrock I,Schauer C,Scheffold A,Scherer HU,Schiemann M,Schildberg FA,Schober K,Schoen J,Schuh W,Schüler T,Schulz AR,Schulz S,Schulze J,Simonetti S,Singh J,Sitnik KM,Stark R,Starossom S,Stehle C,Szelinski F,Tan L,Tarnok A,Tornack J,Tree TIM,van Beek JJP,van de Veen W,van Gisbergen K,Vasco C,Verheyden NA,von Borstel A,Ward-Hartstonge KA,Warnatz K,Waskow C,Wiedemann A,Wilharm A,Wing J,Wirz O,Wittner J,Yang JHM,Yang J
48-0112-82 was used in Flow cytometry/Cell sorting to provide the key aspects to consider when performing flow cytometry experiments.
Wed Dec 01 00:00:00 EST 2021
Tungsten Increases Sex-Specific Osteoclast Differentiation in Murine Bone.
Toxicological sciences : an official journal of the Society of Toxicology
Chou H,Grant MP,Bolt AM,Guilbert C,Plourde D,Mwale F,Mann KK
48-0112-82 was used in Flow Cytometry to demonstrate that tungsten enhances sex-specific osteoclast differentiation.
Wed Jan 06 00:00:00 EST 2021
Inhibition of miR-29 Activity in the Myeloid Lineage Increases Response to Calcitonin and Trabecular Bone Volume in Mice.
Endocrinology
Shin B,Hrdlicka HC,Delany AM,Lee SK
48-0112-82 was used in Flow cytometry/Cell sorting to document an interrelationship between CALCR and CTSK in osteoclastic bone resorption, which is modulated by miR-29-3p.
Fri Oct 01 00:00:00 EDT 2021
Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma.
Scientific reports
Mittal A,Wang M,Vidyarthi A,Yanez D,Pizzurro G,Thakral D,Tracy E,Colegio OR
48-0112-82 was used in Flow Cytometry to demonstrate the therapeutic potential of transcutaneous arginase inhibition in cutaneous squamous cell carcinomas (cSCC).
Mon May 24 00:00:00 EDT 2021
Assessing Lupus-Like Disease in Murine Model Systems.
Current protocols
Lee HY,Celhar T,Fairhurst AM
48-0112-82 was used in Flow Cytometry to evaluate the underlying immunological features of the disease, as a more sensitive strategy to understand the disease itself and the mechanisms of potential novel therapeutics.
Mon Nov 01 00:00:00 EDT 2021
Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure.
Scientific reports
Flamant M,Mougenot N,Balse E,Le Fèvre L,Atassi F,Gautier EL,Le Goff W,Keck M,Nadaud S,Combadière C,Boissonnas A,Pavoine C
48-0112-82 was used in Flow Cytometry to characterize macrophages (Mφ) in hearts early infused with isoproterenol as compared to control and failing hearts and evaluate the role of upregulated CX3CL1 in cardiac remodeling.
Thu Sep 09 00:00:00 EDT 2021
IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.
Frontiers in immunology
Amobi-McCloud A,Muthuswamy R,Battaglia S,Yu H,Liu T,Wang J,Putluri V,Singh PK,Qian F,Huang RY,Putluri N,Tsuji T,Lugade AA,Liu S,Odunsi K
48-0112-82 was used in Flow Cytometry to enable the design of strategies to target the IDO1 and AHR pathways for enhancing anti-tumor immunity in ovarian cancer.
Fri Oct 29 00:00:00 EDT 2021
Isolation and separation of murine tumor-associated macrophages (TAMs) subpopulations from orthotopic 4T1 breast tumors.
STAR protocols
Bieniasz-Krzywiec P,Martín-Pérez R,Riera-Domingo C,Mazzone M
48-0112 was used in Flow cytometry/Cell sorting to describe the complete procedure for isolation and digestion of murine breast cancer samples and fluorescence-activated cell sorting (FACS) of TAMs from murine orthotopic 4T1 breast tumors.
Fri Jun 18 00:00:00 EDT 2021
G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
Nature communications
Gurusamy M,Tischner D,Shao J,Klatt S,Zukunft S,Bonnavion R,Günther S,Siebenbrodt K,Kestner RI,Kuhlmann T,Fleming I,Offermanns S,Wettschureck N
48-0112-82 was used in Flow cytometry/Cell sorting to show that in mice lacking P2Y10 in the CD4 T cell compartment, the severity of experimental autoimmune encephalomyelitis and cutaneous contact hypersensitivity is reduced.
Tue Nov 23 00:00:00 EST 2021
DNA crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia.
Cancer communications (London, England)
Zhang H,Cheng N,Li Z,Bai L,Fang C,Li Y,Zhang W,Dong X,Jiang M,Liang Y,Zhang S,Mi J,Zhu J,Zhang Y,Chen SJ,Zhao Y,Weng XQ,Hu W,Chen Z,Huang J,Meng G
48-0112-82 was used in Flow cytometry/Cell sorting to suggest that DUX4/IGH-driven DNA crosslinking is required for RAG1/2 recruitment onto the double tandem DRE-DRE sites, catalyzing V(D)J-like recombination and oncogenic splicing in acute lymphoblastic leukemia.
Mon Nov 01 00:00:00 EDT 2021
Optimized protocol for immunophenotyping of melanoma and tumor-bearing skin from mouse.
STAR protocols
Krisna SS,Goncalves C,Gagnon N,Huang F,Plourde D,Miller WH,Fritz JH,Del Rincon SV
48-0112-82 was used in Flow cytometry/Cell sorting to determine a protocol for mouse skin isolation and immune cell isolation.
Fri Sep 17 00:00:00 EDT 2021
Mitochondrial ubiquinol oxidation is necessary for tumour growth.
Nature
Martínez-Reyes I,Cardona LR,Kong H,Vasan K,McElroy GS,Werner M,Kihshen H,Reczek CR,Weinberg SE,Gao P,Steinert EM,Piseaux R,Budinger GRS,Chandel NS
48-0112 was used in Flow cytometry/Cell sorting to indicate that tumour growth requires the ETC to oxidize ubiquinol, which is essential to drive the oxidative TCA cycle and DHODH activity.
Tue Sep 01 00:00:00 EDT 2020
The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching.
Immunity
Xu J,Zanvit P,Hu L,Tseng PY,Liu N,Wang F,Liu O,Zhang D,Jin W,Guo N,Han Y,Yin J,Cain A,Hoon MA,Wang S,Chen W
48-0112 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying itching associated with cutaneous wound healing, focusing on the contribution of soluble factors released during healing.
Tue Aug 18 00:00:00 EDT 2020
NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction.
Cell metabolism
McElroy GS,Reczek CR,Reyfman PA,Mithal DS,Horbinski CM,Chandel NS
48-0112-82 was used in Flow Cytometry to generate a mouse that conditionally expresses the yeast NADH dehydrogenase (NDI1), a single enzyme that can replace the NAD+ regeneration capability of the 45-subunit mammalian mitochondrial complex I without proton pumping.
Tue Aug 04 00:00:00 EDT 2020
Extreme disruption of heterochromatin is required for accelerated hematopoietic aging.
Blood
Keenan CR,Iannarella N,Naselli G,Bediaga NG,Johanson TM,Harrison LC,Allan RS
48-0112-82 was used in Flow Cytometry to indicate that the hematopoietic system has a remarkable tolerance for major disruptions in chromatin structure and reveal a role for Suv39h2 in depositing sufficient H3K9me3 to protect the entire hematopoietic system from changes associated with premature aging.
Thu Jun 04 00:00:00 EDT 2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell
Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J
48-0112-82 was used in Flow Cytometry to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
Thu Jul 02 00:00:00 EDT 2020
Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2).
Cancer immunology research
Huetter J,Gritzan U,Gutcher I,Doecke WD,Luetke-Eversloh MV,Golfier S,Roider HG,Frisk AL,Hunter J,Pow A,Drake A,Levine Z,Levy O,Azulay M,Barbiro I,Cojocaru G,Vaknin I,Kreft B,Roese L
48-0112 was used in Flow cytometry/Cell sorting to show that BAY 1905254 is a potential drug candidate for cancer immunotherapy.
Wed Jul 01 00:00:00 EDT 2020
IL-13 Ameliorates Neuroinflammation and Promotes Functional Recovery after Traumatic Brain Injury.
Journal of immunology (Baltimore, Md. : 1950)
Miao W,Zhao Y,Huang Y,Chen D,Luo C,Su W,Gao Y
48-0112 was used in Flow cytometry/Cell sorting to demonstrate that IL-13 treatment improved neurologic outcomes after Traumatic Brain Injury through adjusting microglia/macrophage phenotypes and inhibiting inflammatory responses.
Sun Mar 15 00:00:00 EDT 2020
High-fat diet induced central adiposity (visceral fat) is associated with increased fibrosis and decreased immune cellularity of the mesenteric lymph node in mice.
European journal of nutrition
Magnuson AM,Regan DP,Booth AD,Fouts JK,Solt CM,Hill JL,Dow SW,Foster MT
48-0112-82 was used in Flow Cytometry to investigate if lymph nodes are inherently distinct and differentially respond to diet-induced obesity much like the adipose depots they reside in.
Mon Jun 01 00:00:00 EDT 2020
The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response.
Journal of immunology research
Fu W,Li H,Fu H,Zhao S,Shi W,Sun M,Li Y
48-0112-82 was used in Flow Cytometry to identify that SIRT3 and SIRT6 are key regulators of necroptosis during prostate cancer progression.
Mon Aug 23 00:00:00 EDT 2021
Control of Viral Infection by Natural Killer Cell Inhibitory Receptors.
Cell reports
Parikh BA,Bern MD,Piersma SJ,Yang L,Beckman DL,Poursine-Laurent J,Plougastel-Douglas B,Yokoyama WM
48-0112 was used in Flow cytometry/Cell sorting to show MHC-I-restricted control of murine cytomegalovirus (MCMV) infection in vivo that is NK cell dependent.
Tue Jul 28 00:00:00 EDT 2020
MRI of tumor T cell infiltration in response to checkpoint inhibitor therapy.
Journal for immunotherapy of cancer
Jiang X,Dudzinski S,Beckermann KE,Young K,McKinley E,J McIntyre O,Rathmell JC,Xu J,Gore JC
48-0112-82 was used in Flow Cytometry to propose an innovative concept that a sufficiently large influx of tumor infiltrating T cells, which have a smaller diameter than cancer cells, will change the diameter distribution and decrease the average size of cells within a volume to a degree that can be quantified by non-invasive MRI.
Mon Jun 01 00:00:00 EDT 2020
A rationally-engineered IL-2 improves the antitumor effect of anti-CD20 therapy.
Oncoimmunology
Casadesús AV,Deligne C,Diallo BK,Sosa K,Josseaume N,Mesa C,León K,Hernández T,Teillaud JL
48-0112 was used in Flow cytometry/Cell sorting to show that the combination of anti-tumor antibodies and no-alpha mutein is a promising approach to improve the therapeutic effect of these antibodies by potentiating NK/macrophage-mediated innate immunity and the adaptive T-cell response.
Tue Jun 02 00:00:00 EDT 2020
Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes.
bioRxiv : the preprint server for biology
Karki R,Sharma BR,Tuladhar S,Williams EP,Zalduondo L,Samir P,Zheng M,Sundaram B,Banoth B,Malireddi RKS,Schreiner P,Neale G,Vogel P,Webby R,Jonsson CB,Kanneganti TD
48-0112 was used in Flow cytometry/Cell sorting to reveal that blocking the COVID-19 cytokine-mediated inflammatory cell death signaling pathway identified in this study may benefit patients with COVID-19 or other cytokine storm-driven syndromes by limiting inflammation and tissue damage.
Fri Nov 13 00:00:00 EST 2020
EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity.
eLife
Frye M,Stritt S,Ortsäter H,Hernandez Vasquez M,Kaakinen M,Vicente A,Wiseman J,Eklund L,Martínez-Torrecuadrada JL,Vestweber D,Mäkinen T
48-0112 was used in Flow cytometry/Cell sorting to identify the transmembrane ligand EphrinB2 and its receptor EphB4 as critical homeostatic regulators of collecting lymphatic vessel integrity.
Tue Sep 08 00:00:00 EDT 2020
Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.
Nature communications
Han Y,Jia Q,Jahani PS,Hurrell BP,Pan C,Huang P,Gukasyan J,Woodward NC,Eskin E,Gilliland FD,Akbari O,Hartiala JA,Allayee H
48-0112 was used in Flow cytometry/Cell sorting to elucidate the genetic architecture of asthma and provide important insight into the immunological and sex-specific relevance of asthma-associated risk variants.
Wed Apr 15 00:00:00 EDT 2020
Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer.
JCI insight
Karki R,Sharma BR,Lee E,Banoth B,Malireddi RKS,Samir P,Tuladhar S,Mummareddy H,Burton AR,Vogel P,Kanneganti TD
48-0112 was used in Flow cytometry/Cell sorting to identify IRF1 as an upstream regulator of PANoptosis to induce cell death during colitis-associated tumorigenesis.
Thu Jun 18 00:00:00 EDT 2020
β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis.
Nature communications
Giannini S,Lee-Sundlov MM,Rivadeneyra L,Di Buduo CA,Burns R,Lau JT,Falet H,Balduini A,Hoffmeister KM
48-0112 was used in Flow cytometry/Cell sorting to identify the conserved B4galt1 gene as a critical regulator of thrombopoiesis in megakaryocytes.
Fri Jan 17 00:00:00 EST 2020
The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development.
The Journal of biological chemistry
Kesavardhana S,Malireddi RKS,Burton AR,Porter SN,Vogel P,Pruett-Miller SM,Kanneganti TD
48-0112 was used in Flow cytometry/Cell sorting to identify the essential role of the Zα2 domain of Z-DNA-binding protein 1(ZBP1) in several physiological functions and establish a link between Z-RNA sensing via the Zα2 domain and promotion of influenza-induced pyroptosis, necroptosis, and apoptosis(PANoptosis) and perinatal lethality.
Fri Jun 12 00:00:00 EDT 2020
Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.
Immunity
Dmitrieva-Posocco O,Dzutsev A,Posocco DF,Hou V,Yuan W,Thovarai V,Mufazalov IA,Gunzer M,Shilovskiy IP,Khaitov MR,Trinchieri G,Waisman A,Grivennikov SI
48-0112-82 was used in Flow Cytometry to examine the impact of IL-1 signaling, a key regulator of the IL-17 pathway, in different cell types within the CRC microenvironment.
Tue Jan 15 00:00:00 EST 2019
Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice.
Nature immunology
Piliponsky AM,Shubin NJ,Lahiri AK,Truong P,Clauson M,Niino K,Tsuha AL,Nedospasov SA,Karasuyama H,Reber LL,Tsai M,Mukai K,Galli SJ
48-0112 was used in Flow cytometry/Cell sorting to demonstrate that basophil-deficient mice exhibit reduced bacterial clearance and increased morbidity and mortality in the cecal ligation and puncture (CLP) model of sepsis.
Fri Feb 01 00:00:00 EST 2019
ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination.
The EMBO journal
Ren G,Zhang X,Xiao Y,Zhang W,Wang Y,Ma W,Wang X,Song P,Lai L,Chen H,Zhan Y,Zhang J,Yu M,Ge C,Li C,Yin R,Yang X
48-0112 was used in Flow cytometry/Cell sorting to study an ABRO1-mediated regulatory signaling system that controls activation of the NLRP3 inflammasome.
Fri Mar 15 00:00:00 EDT 2019
Fetal liver Mll-AF4+ hematopoietic stem and progenitor cells respond directly to poly(I:C), but not to a single maternal immune activation.
Experimental hematology
Malouf C,Ottersbach K
48-0112-82 was used in Flow Cytometry to assess if the cell-of-origin of t(4;11) MLL-AF4 acute leukemia is sensitive to a viral or bacterial mimic and if maternal immune activation can lead to a full-blown leukemia.
Thu Aug 01 00:00:00 EDT 2019
MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.
Journal for immunotherapy of cancer
Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y
48-0112-82 was used in Flow cytometry/Cell sorting to demonstrate that p53 activation mediated by APG-115 promotes antitumor immunity in the tumor microenvironment (TME) regardless of the Trp53 status of tumors per se.
Thu Nov 28 00:00:00 EST 2019
Peritoneal Cells Mediate Immune Responses and Cross-Protection Against Influenza A Virus.
Frontiers in immunology
Gautam A,Park BK,Kim TH,Akauliya M,Kim D,Maharjan S,Park J,Kim J,Lee H,Park MS,Lee Y,Kwon HJ
48-0112-82 was used in Flow Cytometry to show that intraperitoneal inoculation with A/WSN/1933 (H1N1) virus induced virus-reactive IgG production in the peritoneal cavity in mice.
Mon Aug 17 00:00:00 EDT 2020
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.
Nature communications
Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM
48-0112 was used in Flow cytometry/Cell sorting to study polysaccharide A as an immunomodulatory symbiosis factor whcih coordinates anti-inflammatory responses during viral infections.
Tue May 14 00:00:00 EDT 2019
Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses.
Nature communications
Kurelac I,Iommarini L,Vatrinet R,Amato LB,De Luise M,Leone G,Girolimetti G,Umesh Ganesh N,Bridgeman VL,Ombrato L,Columbaro M,Ragazzi M,Gibellini L,Sollazzo M,Feichtinger RG,Vidali S,Baldassarre M,Foriel S,Vidone M,Cossarizza A,Grifoni D,Kofler B,Malanchi I,Porcelli AM,Gasparre G
48-0112-82 was used in Flow Cytometry to demonstrate that respiratory complex I-deficient tumours survive and carry out angiogenesis, despite their inability to stabilise Hypoxia Inducible Factor-1 alpha.
Fri Feb 22 00:00:00 EST 2019
A Humanized Bone Niche Model Reveals Bone Tissue Preservation Upon Targeting Mitochondrial Complex I in Pseudo-Orthotopic Osteosarcoma.
Journal of clinical medicine
Kurelac I,Abarrategi A,Ragazzi M,Iommarini L,Umesh Ganesh N,Snoeks T,Bonnet D,Porcelli AM,Malanchi I,Gasparre G
48-0112 was used in Flow cytometry/Cell sorting to characterize the tumour microenvironment of mitochondrial complex I deficient tumors in a model that represents osteosarcoma development.
Wed Dec 11 00:00:00 EST 2019
miR-21 Expression Determines the Early Vaccine Immunity Induced by LdCen-/- Immunization.
Frontiers in immunology
Gannavaram S,Bhattacharya P,Siddiqui A,Ismail N,Madhavan S,Nakhasi HL
48-0112-82 was used in Flow Cytometry to demonstrate that LdCen -/- infection suppresses miR-21 expression, enables IL12 mediated induction of adaptive immunity including proliferation of antigen experienced CD4+ T cells and development of a Th1 immunity, and suggest that miR-21 could be an important biomarker for LdCen -/- vaccine immunity in human clinical trials.
Mon Oct 26 00:00:00 EDT 2020
Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes.
Nature communications
Galle-Treger L,Sankaranarayanan I,Hurrell BP,Howard E,Lo R,Maazi H,Lewis G,Banie H,Epstein AL,Hu P,Rehan VK,Gilliland FD,Allayee H,Soroosh P,Sharpe AH,Akbari O
48-0112-82 was used in Flow Cytometry to show that GITR, a member of the TNF superfamily, is expressed on both murine and human Type-2 innate lymphoid cells.
Tue Feb 12 00:00:00 EST 2019
TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity.
Cell reports
Hurrell BP,Galle-Treger L,Jahani PS,Howard E,Helou DG,Banie H,Soroosh P,Akbari O
48-0112 was used in Flow cytometry/Cell sorting to investigate the role of TNF/TNFR2 axis in pulmonary ILC2s for possible use in treating ILC2-dependent asthma, in murine and human subjects.
Tue Dec 24 00:00:00 EST 2019
Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra.
Nature microbiology
Ji DX,Yamashiro LH,Chen KJ,Mukaida N,Kramnik I,Darwin KH,Vance RE
48-0112 was used in Flow cytometry/Cell sorting to show that enhanced production of type I IFNs was responsible for the susceptibility of B6.Sst1S mice to Mycobacterium tuberculosis (Mtb).
Sun Dec 01 00:00:00 EST 2019
Toll like receptor 7 expressed by malignant cells promotes tumor progression and metastasis through the recruitment of myeloid derived suppressor cells.
Oncoimmunology
Dajon M,Iribarren K,Petitprez F,Marmier S,Lupo A,Gillard M,Ouakrim H,Victor N,Vincenzo DB,Joubert PE,Kepp O,Kroemer G,Alifano M,Damotte D,Cremer I
48-0112 was used in Flow cytometry/Cell sorting to identify the role of TLR7 in the recruitment of myeloid derived suppressor cells resulting in accelerated tumor growth and metastasis in lung adenocarcinoma.
Tue Jan 12 00:00:00 EST 2021
Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy.
Cell reports
Hirukawa A,Singh S,Wang J,Rennhack JP,Swiatnicki M,Sanguin-Gendreau V,Zuo D,Daldoul K,Lavoie C,Park M,Andrechek ER,Westbrook TF,Harris LN,Varadan V,Smith HW,Muller WJ
48-0112-82 was used in Flow cytometry/Cell sorting to provide evidence that EZH2 inhibitors promote interferon-driven immune responses that enhance the efficacy of anti-ErbB2 mAbs, suggesting the potential clinical benefit of epigenomic reprogramming by H3K27me3 depletion in Trastuzumab-resistant disease.
Tue Oct 08 00:00:00 EDT 2019
Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction.
Immunity
Li X,Gadzinsky A,Gong L,Tong H,Calderon V,Li Y,Kitamura D,Klein U,Langdon WY,Hou F,Zou YR,Gu H
48-0112-82 was used in Flow Cytometry to show that deleting E3 ubiquitin ligases Cbl and Cbl-b (Cbls) in GC B cells results in the early exit of high-affinity antigen-specific B cells from the GC reaction and thus impaired clonal expansion.
Tue Mar 20 00:00:00 EDT 2018
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
48-0112 was used in Flow cytometry/Cell sorting to study circular RNA-mediated maintenance of hematopoeitic stem cell homeostasis.
Tue Apr 17 00:00:00 EDT 2018
PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.
Cell stem cell
Hsu JI,Dayaram T,Tovy A,De Braekeleer E,Jeong M,Wang F,Zhang J,Heffernan TP,Gera S,Kovacs JJ,Marszalek JR,Bristow C,Yan Y,Garcia-Manero G,Kantarjian H,Vassiliou G,Futreal PA,Donehower LA,Takahashi K,Goodell MA
48-0112 was used in Flow cytometry/Cell sorting to establish the clinical relevance of PPM1D mutations in clonal haematopoiesis and the importance of studying mutation-treatment interactions.
Thu Nov 01 00:00:00 EDT 2018
Microglia are required for protection against lethal coronavirus encephalitis in mice.
The Journal of clinical investigation
Wheeler DL,Sariol A,Meyerholz DK,Perlman S
48-0112 was used in Flow cytometry/Cell sorting to study the specific roles of microglia in response to infection with the mouse hepatitis virus.
Thu Mar 01 00:00:00 EST 2018
Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.
Frontiers in immunology
Liu R,King A,Bouillet P,Tarlinton DM,Strasser A,Heierhorst J
48-0112 was used in Flow cytometry/Cell sorting to indicate that BIM regulates B cell homeostasis predominantly by limiting the life span of non-activated mature B cells.
Wed May 01 00:00:00 EDT 2019
Macrophages orchestrate breast cancer early dissemination and metastasis.
Nature communications
Linde N,Casanova-Acebes M,Sosa MS,Mortha A,Rahman A,Farias E,Harper K,Tardio E,Reyes Torres I,Jones J,Condeelis J,Merad M,Aguirre-Ghiso JA
48-0112 was used in Flow cytometry/Cell sorting to show that, in pre-malignant lesions, CCL2 produced by cancer cells and myeloid cells attracts CD206+/Tie2+macrophages and induces Wnt-1 upregulation that in turn downregulates E-cadherin junctions in the HER2+early cancer cells.
Tue Jan 02 00:00:00 EST 2018
IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke.
JCI insight
Zhang SR,Piepke M,Chu HX,Broughton BR,Shim R,Wong CH,Lee S,Evans MA,Vinh A,Sakkal S,Arumugam TV,Magnus T,Huber S,Gelderblom M,Drummond GR,Sobey CG,Kim HA
48-0112 was used in Flow cytometry/Cell sorting to study the use of a Th2-promoting agent to provide neuroprotection without adverse systemic effects when given in combination with antibiotics.
Thu Sep 20 00:00:00 EDT 2018
Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points.
Epigenetics & chromatin
Heuston EF,Keller CA,Lichtenberg J,Giardine B,Anderson SM,Hardison RC,Bodine DM
48-0112 was used in Flow cytometry/Cell sorting to demonstrate that megakaryopoietic profiles are established early in haematopoiesis and are present in the majority of the haematopoietic progenitor population.
Mon May 28 00:00:00 EDT 2018
STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia.
Cell reports
Saint Fleur-Lominy S,Maus M,Vaeth M,Lange I,Zee I,Suh D,Liu C,Wu X,Tikhonova A,Aifantis I,Feske S
48-0112 was used in Flow cytometry/Cell sorting to investigate the role of store-operated Ca2+ entry mediated by ORAI1, and STIM1 and STIM2 in T-cell acute lymphoblastic leukaemia.
Tue Sep 11 00:00:00 EDT 2018
Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia.
JCI insight
Hua X,Vijay R,Channappanavar R,Athmer J,Meyerholz DK,Pagedar N,Tilley S,Perlman S
48-0112 was used in Flow cytometry/Cell sorting to study the mechanisms by which nasal inoculation of murine coronavirus in the absence of direct lung infection primes the lung immune environment.
Thu Jun 07 00:00:00 EDT 2018
Adipose tissue extrinsic factor: Obesity-induced inflammation and the role of the visceral lymph node.
Physiology & behavior
Magnuson AM,Fouts JK,Regan DP,Booth AD,Dow SW,Foster MT
48-0112-82 was used in Flow cytometry/Cell sorting to elucidate how the lymphatic system may contribute to the comorbidities associated with visceral adipose tissue accumulation.
Fri Jun 01 00:00:00 EDT 2018
MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.
Frontiers in immunology
Knolle MD,Chin SB,Rana BMJ,Englezakis A,Nakagawa R,Fallon PG,Git A,McKenzie ANJ
48-0112 was used in Flow cytometry/Cell sorting to identify a subset of micro-RNAs that are regulated upon group-2 innate lymphoid cells (ILC2) activation, and establish a specific role for miR-155 in regulating ILC2 survival following activation.
Mon Sep 30 00:00:00 EDT 2019
A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy.
Nature communications
Lee RS,Waters AP,Brewer JM
48-0112 was used in Flow cytometry/Cell sorting to enumerate Plasmodium infected erythropoietic precursor cells using an in vivo rodent model of Plasmodium berghei.
Fri Apr 27 00:00:00 EDT 2018
Characterization of the Inflammatory Response in Dystrophic Muscle Using Flow Cytometry.
Methods in molecular biology (Clifton, N.J.)
Kastenschmidt JM,Avetyan I,Villalta SA
48-0112 was used in Flow cytometry/Cell sorting to highlight methods for the isolation and study of immune cell populations from muscles of mouse models of DMD.
Tue Jun 05 00:00:00 EDT 2018
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program.
Nature communications
Frye M,Taddei A,Dierkes C,Martinez-Corral I,Fielden M,Ortsäter H,Kazenwadel J,Calado DP,Ostergaard P,Salminen M,He L,Harvey NL,Kiefer F,Mäkinen T
48-0112 was used in Flow cytometry/Cell sorting to study whether extracellular matrix stiffness impacts lymphatic vascular development.
Tue Apr 17 00:00:00 EDT 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
48-0112 was used in Flow cytometry/Cell sorting to study paediatric acute myeloid leukaemia biology, and provide murine models that offer the potential for developing paediatric specific therapeutic strategies.
Tue Dec 11 00:00:00 EST 2018
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Nature medicine
Schneider C,Oellerich T,Baldauf HM,Schwarz SM,Thomas D,Flick R,Bohnenberger H,Kaderali L,Stegmann L,Cremer A,Martin M,Lohmeyer J,Michaelis M,Hornung V,Schliemann C,Berdel WE,Hartmann W,Wardelmann E,Comoglio F,Hansmann ML,Yakunin AF,Geisslinger G,Ströbel P,Ferreirós N,Serve H,Keppler OT,Cinatl J
48011282 was used in flow cytometry to demonstrate that SAMHD1 reduces nucleoside analog cytarabine cytotoxicity in acute myeloid leukemia cells
Wed Feb 01 00:00:00 EST 2017
Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells.
Immunity
Hayatsu N,Miyao T,Tachibana M,Murakami R,Kimura A,Kato T,Kawakami E,Endo TA,Setoguchi R,Watarai H,Nishikawa T,Yasuda T,Yoshida H,Hori S
48-0112 was used in Flow cytometry/Cell sorting to identify BATF as a regulator of tissue regulatory T cells and suggest that sequence-specific perturbations of Foxp3-DNA interactions can influence specific facets of Treg physiology and the immunopathologies.
Tue Aug 15 00:00:00 EDT 2017
Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.
Cancer cell
Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH
48-0112 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic advantage of using an immunomodulatory mAb to regulate lymphoid cells, which then recruit and activate myeloid cells for enhanced killing of mAb-opsonized tumors.
Mon Dec 11 00:00:00 EST 2017
Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.
Cancer cell
Mohr S,Doebele C,Comoglio F,Berg T,Beck J,Bohnenberger H,Alexe G,Corso J,Ströbel P,Wachter A,Beissbarth T,Schnütgen F,Cremer A,Haetscher N,Göllner S,Rouhi A,Palmqvist L,Rieger MA,Schroeder T,Bönig H,Müller-Tidow C,Kuchenbauer F,Schütz E,Green AR,Urlaub H,Stegmaier K,Humphries RK,Serve H,Oellerich T
48-0112 was used in Flow cytometry/Cell sorting to study the effects of combined Hoxa9/Meis1 over-expression on intracellular signalling, and whether cells transformed by Hoxa9 and Meis1 become addicted to targetable signalling processes.
Mon Apr 10 00:00:00 EDT 2017
Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.
Cell metabolism
Westerterp M,Gautier EL,Ganda A,Molusky MM,Wang W,Fotakis P,Wang N,Randolph GJ,D'Agati VD,Yvan-Charvet L,Tall AR
48-0112 was used in Flow cytometry/Cell sorting to identify an essential role of DC cholesterol efflux pathways in maintaining immune tolerance.
Tue Jun 06 00:00:00 EDT 2017
Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.
Cell stem cell
Schneider RK,Mullally A,Dugourd A,Peisker F,Hoogenboezem R,Van Strien PMH,Bindels EM,Heckl D,Büsche G,Fleck D,Müller-Newen G,Wongboonsin J,Ventura Ferreira M,Puelles VG,Saez-Rodriguez J,Ebert BL,Humphreys BD,Kramann R
48-0112 was used in Flow cytometry/Cell sorting to study the cellular origin of bone marrow fibrosis.
Thu Jun 01 00:00:00 EDT 2017
TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.
The Journal of experimental medicine
Schweighoffer E,Nys J,Vanes L,Smithers N,Tybulewicz VLJ
48-0112 was used in Flow cytometry/Cell sorting to demonstrate two distinct signalling pathways for TLR4, one via the BCR and the other through MYD88.
Mon May 01 00:00:00 EDT 2017
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
The Journal of experimental medicine
Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG
48-0112 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.
Mon Sep 04 00:00:00 EDT 2017
Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease.
EMBO molecular medicine
Oak P,Pritzke T,Thiel I,Koschlig M,Mous DS,Windhorst A,Jain N,Eickelberg O,Foerster K,Schulze A,Goepel W,Reicherzer T,Ehrhardt H,Rottier RJ,Ahnert P,Gortner L,Desai TJ,Hilgendorff A
48-0112 was used in Flow cytometry/Cell sorting to discover attenuated PDGF signalling as a driver of neonatal chronic lung disease and provision of PDGF-A as a protective strategy.
Wed Nov 01 00:00:00 EDT 2017
Virus-induced inflammasome activation is suppressed by prostaglandin D2/DP1 signaling.
Proceedings of the National Academy of Sciences of the United States of America
Vijay R,Fehr AR,Janowski AM,Athmer J,Wheeler DL,Grunewald M,Sompallae R,Kurup SP,Meyerholz DK,Sutterwala FS,Narumiya S,Perlman S
48-0112 was used in Flow cytometry/Cell sorting to study the role of Prostaglandin D2 signalling in optimal microglia/macrophage activation and interferon expression after infection with a neurotropic coronavirus.
Mon Jul 03 00:00:00 EDT 2017
IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.
PLoS medicine
Xu J,Guardado J,Hoffman R,Xu H,Namas R,Vodovotz Y,Xu L,Ramadan M,Brown J,Turnquist HR,Billiar TR
48-0112 was used in Flow cytometry/Cell sorting to suggest that IL33 may initiate early detrimental type 2 immune responses after trauma through ILC2 regulation of neutrophil IL5 production.
Sat Jul 01 00:00:00 EDT 2017
Inhibition of the NOD-Like Receptor Protein 3 Inflammasome Is Protective in Juvenile Influenza A Virus Infection.
Frontiers in immunology
Coates BM,Staricha KL,Ravindran N,Koch CM,Cheng Y,Davis JM,Shumaker DK,Ridge KM
48-0112 was used in Flow cytometry/Cell sorting to demonstrate that during Influenza A Virus infection, inhibition of the NOD-like receptor protein 3 inflammasome was successful in alleviating damage to lung tissues, usually caused by the host immune response to the virus.
Mon Apr 25 00:00:00 EDT 2022
Diet-induced obesity causes visceral, but not subcutaneous, lymph node hyperplasia via increases in specific immune cell populations.
Cell proliferation
Magnuson AM,Regan DP,Fouts JK,Booth AD,Dow SW,Foster MT
48-0112 was used in Flow cytometry/Cell sorting to investigate whether secondary lymphatics within visceral adiposity contribute to disease risk.
Sun Oct 01 00:00:00 EDT 2017
MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.
PLoS pathogens
Friedrich C,Mamareli P,Thiemann S,Kruse F,Wang Z,Holzmann B,Strowig T,Sparwasser T,Lochner M
48-0112 was used in Flow cytometry/Cell sorting to suggest that MyD88 signaling in DC and IEC is both essential and sufficient to induce a full spectrum of host responses upon intestinal infection with C. rodentium.
Mon May 01 00:00:00 EDT 2017
Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity.
Development (Cambridge, England)
Wang Y,Jin Y,Mäe MA,Zhang Y,Ortsäter H,Betsholtz C,Mäkinen T,Jakobsson L
48-0112 was used in Flow cytometry/Cell sorting to demonstrate that platelet-derived growth factor B regulates lymphatic smooth muscle cell recruitment in multiple vascular beds.
Sun Oct 01 00:00:00 EDT 2017
Guidelines for the use of flow cytometry and cell sorting in immunological studies.
European journal of immunology
Cossarizza A,Chang HD,Radbruch A,Akdis M,Andrä I,Annunziato F,Bacher P,Barnaba V,Battistini L,Bauer WM,Baumgart S,Becher B,Beisker W,Berek C,Blanco A,Borsellino G,Boulais PE,Brinkman RR,Büscher M,Busch DH,Bushnell TP,Cao X,Cavani A,Chattopadhyay PK,Cheng Q,Chow S,Clerici M,Cooke A,Cosma A,Cosmi L,Cumano A,Dang VD,Davies D,De Biasi S,Del Zotto G,Della Bella S,Dellabona P,Deniz G,Dessing M,Diefenbach A,Di Santo J,Dieli F,Dolf A,Donnenberg VS,Dörner T,Ehrhardt GRA,Endl E,Engel P,Engelhardt B,Esser C,Everts B,Dreher A,Falk CS,Fehniger TA,Filby A,Fillatreau S,Follo M,Förster I,Foster J,Foulds GA,Frenette PS,Galbraith D,Garbi N,García-Godoy MD,Geginat J,Ghoreschi K,Gibellini L,Goettlinger C,Goodyear CS,Gori A,Grogan J,Gross M,Grützkau A,Grummitt D,Hahn J,Hammer Q,Hauser AE,Haviland DL,Hedley D,Herrera G,Herrmann M,Hiepe F,Holland T,Hombrink P,Houston JP,Hoyer BF,Huang B,Hunter CA,Iannone A,Jäck HM,Jávega B,Jonjic S,Juelke K,Jung S,Kaiser T,Kalina T,Keller B,Khan S,Kienhöfer D,Kroneis T,Kunkel D,Kurts C,Kvistborg P,Lannigan J,Lantz O,Larbi A,LeibundGut-Landmann S,Leipold MD,Levings MK,Litwin V,Liu Y,Lohoff M,Lombardi G,Lopez L,Lovett-Racke A,Lubberts E,Ludewig B,Lugli E,Maecker HT,Martrus G,Matarese G,Maueröder C,McGrath M,McInnes I,Mei HE,Melchers F,Melzer S,Mielenz D,Mills K,Mirrer D,Mjösberg J,Moore J,Moran B,Moretta A,Moretta L,Mosmann TR,Müller S,Müller W,Münz C,Multhoff G,Munoz LE,Murphy KM,Nakayama T,Nasi M,Neudörfl C,Nolan J,Nourshargh S,O'Connor JE,Ouyang W,Oxenius A,Palankar R,Panse I,Peterson P,Peth C,Petriz J,Philips D,Pickl W,Piconese S,Pinti M,Pockley AG,Podolska MJ,Pucillo C,Quataert SA,Radstake TRDJ,Rajwa B,Rebhahn JA,Recktenwald D,Remmerswaal EBM,Rezvani K,Rico LG,Robinson JP,Romagnani C,Rubartelli A,Ruckert B,Ruland J,Sakaguchi S,Sala-de-Oyanguren F,Samstag Y,Sanderson S,Sawitzki B,Scheffold A,Schiemann M,Schildberg F,Schimisky E,Schmid SA,Schmitt S,Schober K,Schüler T,Schulz AR,Schumacher T,Scotta C,Shankey TV,Shemer A,Simon AK,Spidlen J,Stall AM,Stark R,Stehle C,Stein M,Steinmetz T,Stockinger H,Takahama Y,Tarnok A,Tian Z,Toldi G,Tornack J,Traggiai E,Trotter J,Ulrich H,van der Braber M,van Lier RAW,Veldhoen M,Vento-Asturias S,Vieira P,Voehringer D,Volk HD,von Volkmann K,Waisman A,Walker R,Ward MD,Warnatz K,Warth S,Watson JV,Watzl C,Wegener L,Wiedemann A,Wienands J,Willimsky G,Wing J,Wurst P,Yu L,Yue A,Zhang Q,Zhao Y,Ziegler S,Zimmermann J
48-0112 was used in Flow cytometry/Cell sorting to collect the currently accepted best methods for monitoring most of the variation of the major players of immune system.
Sun Oct 01 00:00:00 EDT 2017
Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells.
Nature communications
Downs-Canner S,Berkey S,Delgoffe GM,Edwards RP,Curiel T,Odunsi K,Bartlett DL,Obermajer N
48-0112 was used in Flow cytometry/Cell sorting to demonstrate the tumour-associated conversion of Th17 cells to Treg cells and identify transdifferentiation-associated markers.
Tue Mar 14 00:00:00 EDT 2017
Location of tumor affects local and distant immune cell type and number.
Immunity, inflammation and disease
Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S
48-0112 was used in Flow cytometry/Cell sorting to demonstrate that location of tumour, and not simply the tumour itself, has a definitive role in regulating immune effectors.
Wed Mar 01 00:00:00 EST 2017
The tyrosine kinase inhibitor imatinib mesylate suppresses uric acid crystal-induced acute gouty arthritis in mice.
PloS one
Reber LL,Starkl P,Balbino B,Sibilano R,Gaudenzio N,Rogalla S,Sensarn S,Kang D,Raghu H,Sokolove J,Robinson WH,Contag CH,Tsai M,Galli SJ
48-0112 was used in Flow cytometry/Cell sorting to demonstrate that treatment with imatinib mesylate can suppress inflammation induced by injection of monosodium urate crystals into subcutaneous air pouches or into the ankle joint of wild type mice.
Tue Oct 31 00:00:00 EDT 2017
The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.
Nature communications
Ratsimandresy RA,Chu LH,Khare S,de Almeida L,Gangopadhyay A,Indramohan M,Misharin AV,Greaves DR,Perlman H,Dorfleutner A,Stehlik C
48-0112 was used in Flow cytometry/Cell sorting to investigate the complex interactions governing inflammasome assembly and function.
Mon Jun 05 00:00:00 EDT 2017
IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis.
Scientific reports
Peshkova IO,Fatkhullina AR,Mikulski Z,Ley K,Koltsova EK
48-0112 was used in Flow cytometry/Cell sorting to study the role of IL-27R in controlling myeloid cell accumulation and activation in atherosclerosis.
Tue May 23 00:00:00 EDT 2017
The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis.
Oncoimmunology
Dagenais M,Dupaul-Chicoine J,Douglas T,Champagne C,Morizot A,Saleh M
48-0112 was used in Flow cytometry/Cell sorting to genetically investigate the role of the interleukin-1 receptor 1 pathway in breast cancer tumourigenesis and metastasis using a mouse model.
Tue Jan 12 00:00:00 EST 2021
NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer.
Nature
Karki R,Man SM,Malireddi RKS,Kesavardhana S,Zhu Q,Burton AR,Sharma BR,Qi X,Pelletier S,Vogel P,Rosenstiel P,Kanneganti TD
48-0112 was used in Flow cytometry/Cell sorting to explore a key role for NLRC3 in mediating protection against colorectal cancer.
Thu Dec 22 00:00:00 EST 2016
IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.
Cell
Man SM,Karki R,Sasai M,Place DE,Kesavardhana S,Temirov J,Frase S,Zhu Q,Malireddi RKS,Kuriakose T,Peters JL,Neale G,Brown SA,Yamamoto M,Kanneganti TD
48-0112 was used in Flow cytometry/Cell sorting to show that the interferon-inducible protein IRGB10 is essential for activation of the DNA-sensing AIM2 inflammasome by Francisella novicida.
Thu Oct 06 00:00:00 EDT 2016
Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells.
The Journal of clinical investigation
Dileepan T,Smith ED,Knowland D,Hsu M,Platt M,Bittner-Eddy P,Cohen B,Southern P,Latimer E,Harley E,Agalliu D,Cleary PP
48-0112 was used in Flow cytometry/Cell sorting to elucidate the immunopathological contribution of Group A streptococci (GAS)-specific CD4+ T cells in the induced neuropathology following infection with GAS.
Fri Jan 01 00:00:00 EST 2016
Immunomodulatory nanoparticles ameliorate disease in the Leishmania (Viannia) panamensis mouse model.
Biomaterials
Siefert AL,Ehrlich A,Corral MJ,Goldsmith-Pestana K,McMahon-Pratt D,Fahmy TM
48-0112 was used in Flow cytometry/Cell sorting to study the therapeutic efficacy of biodegradable nanoparticles encapsulating a CpG-rich oligonucleotide in mice infected with Leishmania panamensis.
Tue Nov 01 00:00:00 EDT 2016
SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages.
Autophagy
Kim MJ,Bae SH,Ryu JC,Kwon Y,Oh JH,Kwon J,Moon JS,Kim K,Miyawaki A,Lee MG,Shin J,Kim YS,Kim CH,Ryter SW,Choi AM,Rhee SG,Ryu JH,Yoon JH
48-0112 was used in Flow cytometry/Cell sorting to define a unique regulatory mechanism of mitophagy activation for immunological homeostasis that protects the host from sepsis.
Tue Aug 02 00:00:00 EDT 2016
Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1.
Arteriosclerosis, thrombosis, and vascular biology
Herbin O,Regelmann AG,Ramkhelawon B,Weinstein EG,Moore KJ,Alexandropoulos K
48-0112 was used in Flow cytometry/Cell sorting to analyse the role of Chat-H in atherosclerosis development, showing that monocyte adhesion and plaque recruitment is regulated by Chat-H/SHEP1.
Thu Sep 01 00:00:00 EDT 2016
Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice.
Arteriosclerosis, thrombosis, and vascular biology
Srikakulapu P,Hu D,Yin C,Mohanta SK,Bontha SV,Peng L,Beer M,Weber C,McNamara CA,Grassia G,Maffia P,Manz RA,Habenicht AJ
48-0112 was used in Flow cytometry/Cell sorting to study how artery tertiary lymphoid organs can orchestrate B-cell responses in the diseased aorta.
Wed Jun 01 00:00:00 EDT 2016
Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection.
Mucosal immunology
Dudek M,Puttur F,Arnold-Schrauf C,Kühl AA,Holzmann B,Henriques-Normark B,Berod L,Sparwasser T
48-0112 was used in Flow cytometry/Cell sorting to investigate the extent to which MyD88 signaling is required to control S. pneumoniae infection, showing that lung epithelium and myeloid cells cooperate to clear infection.
Thu Sep 01 00:00:00 EDT 2016
Lineage tracing of cells involved in atherosclerosis.
Atherosclerosis
Albarrán-Juárez J,Kaur H,Grimm M,Offermanns S,Wettschureck N
48-0112 was used in Flow cytometry/Cell sorting to identify the origin of vascular smooth muscle cells and macrophages within atherosclerosis lesions.
Mon Aug 01 00:00:00 EDT 2016
Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Madsen PM,Motti D,Karmally S,Szymkowski DE,Lambertsen KL,Bethea JR,Brambilla R
48-0112 was used in Flow cytometry/Cell sorting to provide evidence that TNFR2 in oligodendrocytes is important for oligodendrocyte differentiation, thereby sustaining tmTNF-dependent repair in neuroimmune disease.
Wed May 04 00:00:00 EDT 2016
Lack of the programmed death-1 receptor renders host susceptible to enteric microbial infection through impairing the production of the mucosal natural killer cell effector molecules.
Journal of leukocyte biology
Solaymani-Mohammadi S,Lakhdari O,Minev I,Shenouda S,Frey BF,Billeskov R,Singer SM,Berzofsky JA,Eckmann L,Kagnoff MF
48-0112 was used in Flow cytometry/Cell sorting to identify the role of the programmed death-1 receptor in early host microbial defence at the intestinal mucosa.
Tue Mar 01 00:00:00 EST 2016
Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile.
Arthritis research & therapy
van der Velden D,Lagraauw HM,Wezel A,Launay P,Kuiper J,Huizinga TW,Toes RE,Bot I,Stoop JN
48-0112 was used in Flow cytometry/Cell sorting to suggest that mast cells may play a role in the regulation of the adaptive immune response during the development of arthritis.
Mon Jun 13 00:00:00 EDT 2016
Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.
Journal of immunology (Baltimore, Md. : 1950)
Skeldon AM,Morizot A,Douglas T,Santoro N,Kursawe R,Kozlitina J,Caprio S,Mehal WZ,Saleh M
48-0112 was used in Flow cytometry/Cell sorting to investigate a role for caspase-11 and caspase-12 in obesity and insulin resistance.
Fri Jan 01 00:00:00 EST 2016
An in vitro model of granuloma-like cell aggregates substantiates early host immune responses against Mycobacterium massiliense infection.
Biology open
Je S,Quan H,Na Y,Cho SN,Kim BJ,Seok SH
48-0112 was used in Flow cytometry/Cell sorting to study the interaction between host cells and Mycobacterium massiliense.
Mon Aug 15 00:00:00 EDT 2016
Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins.
Genesis (New York, N.Y. : 2000)
Ulvmar MH,Martinez-Corral I,Stanczuk L,Mäkinen T
48-0112 was used in Flow cytometry/Cell sorting to show that Pdgfrb-Cre does not target YS HemEC or YS-derived erythro-myeloid progenitors.
Wed Jun 01 00:00:00 EDT 2016
Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.
Cell reports
Barrett NA,Malouf C,Kapeni C,Bacon WA,Giotopoulos G,Jacobsen SEW,Huntly BJ,Ottersbach K
48-0112 was used in Flow cytometry/Cell sorting to elucidate the contribution of MII-AF4 in B cell acute lymphoblastic leukaemia early development in the mouse embryo.
Tue Jul 26 00:00:00 EDT 2016
Characterization of Cells Isolated from Genetic and Trauma-Induced Heterotopic Ossification.
PloS one
Agarwal S,Drake J,Qureshi AT,Loder S,Li S,Shigemori K,Peterson J,Cholok D,Forsberg JA,Mishina Y,Davis TA,Levi B
48-0112 was used in Flow cytometry/Cell sorting to demonstrate that across models, cells derived from tissues forming heterotopic ossification exhibit increased osteogenic differentiation compared to normal tissues or osteoblasts.
Wed Aug 23 00:00:00 EDT 2017
Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-stimulated cAMP Signaling in Murine Osteoblasts.
The Journal of biological chemistry
Choudhary S,Goetjen A,Estus T,Jacome-Galarza CE,Aguila HL,Lorenzo J,Pilbeam C
48-0112 was used in Flow cytometry/Cell sorting to identify the inhibitor of PTH-stimulated osteoblast differentiation.
Fri Feb 19 00:00:00 EST 2016
Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment.
Nature communications
Spanier JA,Frederick DR,Taylor JJ,Heffernan JR,Kotov DI,Martinov T,Osum KC,Ruggiero JL,Rust BJ,Landry SJ,Jenkins MK,McLachlan JB,Fife BT
48-0112 was used in Flow cytometry/Cell sorting to develop a novel approach for the generation and screening of peptide:MHCII reactive mAbs that exploits the use of recombinant peptide:MHC monomers as immunogens.
Mon Jun 13 00:00:00 EDT 2016
Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation.
Nature communications
Jackson-Jones LH,Duncan SM,Magalhaes MS,Campbell SM,Maizels RM,McSorley HJ,Allen JE,Bénézech C
48-0112 was used in Immunofluorescence to reveal a link between inflammation, IL-33 release by FALC stromal cells, ILC2 activation and pleural B-cell activation in FALCs, resulting in local and antigen-specific IgM production.
Thu Sep 01 00:00:00 EDT 2016
Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation.
Nature communications
Jackson-Jones LH,Duncan SM,Magalhaes MS,Campbell SM,Maizels RM,McSorley HJ,Allen JE,Bénézech C
48-0112 was used in Immunofluorescence to reveal a link between inflammation, IL-33 release by FALC stromal cells, ILC2 activation and pleural B-cell activation in FALCs, resulting in local and antigen-specific IgM production.
Thu Sep 01 00:00:00 EDT 2016
Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner.
PloS one
Watanabe N,Kaminuma O,Kitamura N,Hiroi T
48-0112 was used in Flow cytometry/Cell sorting to study whether Th17 and Tregs that promote and suppress inflammatory responses, respectively, work with or against each other in immune reactions, showing that cotransfer of Th17 and induced Tregs led to increased inflammation, and blockage of CTLA4 led to abrogation of this effect.
Mon Aug 01 00:00:00 EDT 2016
Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.
Nature neuroscience
Haines JD,Herbin O,de la Hera B,Vidaurre OG,Moy GA,Sun Q,Fung HY,Albrecht S,Alexandropoulos K,McCauley D,Chook YM,Kuhlmann T,Kidd GJ,Shacham S,Casaccia P
48-0112 was used in Flow cytometry/Cell sorting to reveal that CRM1 inhibitors have the ability to modulate the export of molecules associated with both axonal damage and also neuroprotection.
Wed Apr 01 00:00:00 EDT 2015
Nonvenous origin of dermal lymphatic vasculature.
Circulation research
Martinez-Corral I,Ulvmar MH,Stanczuk L,Tatin F,Kizhatil K,John SW,Alitalo K,Ortega S,Makinen T
48-0112 was used in Flow cytometry/Cell sorting to investigate the origin of murine lymphatic vasculature, showing a significant contribution from nonvenous cells.
Fri May 08 00:00:00 EDT 2015
Effects of growth arrest and DNA damage-inducible protein 34 (GADD34) on inflammation-induced colon cancer in mice.
British journal of cancer
Tanaka Y,Ito S,Oshino R,Chen N,Nishio N,Isobe K
48-0112 was used in Flow cytometry/Cell sorting to investigate how GADD34 up-regulated pro-inflammatory mediator production, leading to a higher tumour burden following AOM/DSS treatment.
Tue Aug 11 00:00:00 EDT 2015
Experimental design of complement component 5a-induced acute lung injury (C5a-ALI): a role of CC-chemokine receptor type 5 during immune activation by anaphylatoxin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Russkamp NF,Ruemmler R,Roewe J,Moore BB,Ward PA,Bosmann M
48-0112 was used in Flow cytometry/Cell sorting to determine that the detrimental effects of C5a are partly mediated through CCR5 activation downstream of C5aR1.
Tue Sep 01 00:00:00 EDT 2015
The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.
Journal of immunology (Baltimore, Md. : 1950)
Douglas T,Champagne C,Morizot A,Lapointe JM,Saleh M
48-0112 was used in Flow cytometry/Cell sorting to implicate the inflammasome as an important initiating signal in skin disease pathogenesis.
Tue Sep 01 00:00:00 EDT 2015
Therapeutic Use of Soluble Fas Ligand Ameliorates Acute and Recurrent Herpetic Stromal Keratitis in Mice.
Investigative ophthalmology & visual science
Rogge M,Yin XT,Godfrey L,Lakireddy P,Potter CA,Del Rosso CR,Stuart PM
48-0112 was used in Flow cytometry/Cell sorting to provide evidence that sFasL treatment has potential therapeutic benefit in reducing inflammatory infiltrate and neovascularization in herpetic stromal keratitis.
Thu Oct 01 00:00:00 EDT 2015
Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice.
Journal of immunology research
Yin XT,Keadle TL,Hard J,Herndon J,Potter CA,Del Rosso CR,Ferguson TA,Stuart PM
48-0112 was used in Flow cytometry/Cell sorting to investigate the role of FasL in herpetic stromal keratitis.
Tue May 24 00:00:00 EDT 2016
The Spleen Plays No Role in Nephrotoxic Serum Nephritis, but Constitutes a Place of Compensatory Haematopoiesis.
PloS one
Artinger K,Kirsch AH,Aringer I,Schabhüttl C,Rosenkranz AR,Eller P,Rho E,Eller K
48-0112 was used in Flow cytometry/Cell sorting to study how splenectomy does not influence the course of NTS, but is involved in concomitant anaemia.
Fri May 06 00:00:00 EDT 2016
Exposure to Leishmania braziliensis triggers neutrophil activation and apoptosis.
PLoS neglected tropical diseases
Falcão SA,Weinkopff T,Hurrell BP,Celes FS,Curvelo RP,Prates DB,Barral A,Borges VM,Tacchini-Cottier F,de Oliveira CI
48-0112 was used in Flow cytometry/Cell sorting to show that L. braziliensis induces neutrophil recruitment in vivo and that neutrophils exposed to the parasite in vitro respond through activation and release of inflammatory mediators.
Sun Mar 01 00:00:00 EST 2015
Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.
PLoS genetics
Gralinski LE,Ferris MT,Aylor DL,Whitmore AC,Green R,Frieman MB,Deming D,Menachery VD,Miller DR,Buus RJ,Bell TA,Churchill GA,Threadgill DW,Katze MG,McMillan L,Valdar W,Heise MT,Pardo-Manuel de Villena F,Baric RS
48-0112 was used in Flow cytometry/Cell sorting to validate the Collaborative Cross platform as a resource for uncovering the genetic contributions of complex traits in microbial diseases, inflammation and viral replication.
Thu Oct 01 00:00:00 EDT 2015
Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production.
PloS one
Molina MA,Díaz AM,Hesse C,Ginter W,Gentilini MV,Nuñez GG,Canellada AM,Sparwasser T,Berod L,Castro MS,Manghi MA
48-0112 was used in Flow cytometry/Cell sorting to elucidate the influence of E. faecalis CECT7121 on dendritic cells and the outcome of the immune responses.
Tue Apr 19 00:00:00 EDT 2016
Natural Killer Cells Mediate Protection against Yersinia pseudotuberculosis in the Mesenteric Lymph Nodes.
PloS one
Rosenheinrich M,Heine W,Schmühl CM,Pisano F,Dersch P
48-0112 was used in Flow cytometry/Cell sorting to characterise the role of natural killer cells in the response to the extracellular bacterial pathogen, yersiniae.
Tue May 10 00:00:00 EDT 2016
A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner.
Cancer discovery
Donohoe DR,Holley D,Collins LB,Montgomery SA,Whitmore AC,Hillhouse A,Curry KP,Renner SW,Greenwalt A,Ryan EP,Godfrey V,Heise MT,Threadgill DS,Han A,Swenberg JA,Threadgill DW,Bultman SJ
48-0112 was used in Flow cytometry/Cell sorting to assess whether dietary fiber is protective in colorectal cancer.
Mon Dec 01 00:00:00 EST 2014
Contribution of mast cell-derived interleukin-1β to uric acid crystal-induced acute arthritis in mice.
Arthritis & rheumatology (Hoboken, N.J.)
Reber LL,Marichal T,Sokolove J,Starkl P,Gaudenzio N,Iwakura Y,Karasuyama H,Schwartz LB,Robinson WH,Tsai M,Galli SJ
48-0112 was used in Flow cytometry/Cell sorting to assess the role of mast cells in a mouse model of monosodium urate monohydrate crystal-induced acute arthritis.
Wed Oct 01 00:00:00 EDT 2014
Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures.
The Journal of allergy and clinical immunology
Gold MJ,Antignano F,Halim TY,Hirota JA,Blanchet MR,Zaph C,Takei F,McNagny KM
48-0112 was used in Flow cytometry/Cell sorting to reveal a critical role for ILC2s in the development of adaptive type 2 responses to local antigen exposure.
Tue Apr 01 00:00:00 EDT 2014
Targeting intestinal inflammation with CD98 siRNA/PEI-loaded nanoparticles.
Molecular therapy : the journal of the American Society of Gene Therapy
Laroui H,Geem D,Xiao B,Viennois E,Rakhya P,Denning T,Merlin D
48-0112 was used in Flow cytometry/Cell sorting to show that CD98 was effectively down-regulated in the intestinal epithelial cells and intestinal macrophages of treated mice.
Wed Jan 01 00:00:00 EST 2014
Blocking junctional adhesion molecule C enhances dendritic cell migration and boosts the immune responses against Leishmania major.
PLoS pathogens
Ballet R,Emre Y,Jemelin S,Charmoy M,Tacchini-Cottier F,Imhof BA
48-0112 was used in Flow cytometry/Cell sorting to illustrate a key role for the vascular adhesion molecule JAM-C in controlling leukocyte migration and subsequent immune events in response to pathogen infections.
Mon Dec 01 00:00:00 EST 2014
Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27.
Journal of leukocyte biology
Bosmann M,Strobl B,Kichler N,Rigler D,Grailer JJ,Pache F,Murray PJ,Müller M,Ward PA
48-0112 was used in Flow cytometry/Cell sorting to investigate factors governing the gene expression and release of IL-27.
Tue Jul 01 00:00:00 EDT 2014
Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice.
Laboratory investigation; a journal of technical methods and pathology
Yang Y,Aloi MS,Cudaback E,Josephsen SR,Rice SJ,Jorstad NL,Keene CD,Montine TJ
48-0112 was used in Flow cytometry/Cell sorting to reveal that BMT can be administered as a stem cell-based approach to prevent or to treat neurodegenerative diseases.
Sat Nov 01 00:00:00 EDT 2014
The NF-κB regulator Bcl-3 governs dendritic cell antigen presentation functions in adaptive immunity.
Journal of immunology (Baltimore, Md. : 1950)
Tassi I,Claudio E,Wang H,Tang W,Ha HL,Saret S,Ramaswamy M,Siegel R,Siebenlist U
48-0112 was used in Flow cytometry/Cell sorting to study the role of Bcl-3 in dendritic cell survival and the generation of adaptive immunity.
Sat Nov 01 00:00:00 EDT 2014
Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3.
Journal of immunology (Baltimore, Md. : 1950)
Bosmann M,Russkamp NF,Strobl B,Roewe J,Balouzian L,Pache F,Radsak MP,van Rooijen N,Zetoune FS,Sarma JV,Núñez G,Müller M,Murray PJ,Ward PA
48-0112 was used in Flow cytometry/Cell sorting to identify IL-10 as a critical suppressing factor for IL-27(p28) production during infection-associated inflammation.
Mon Dec 01 00:00:00 EST 2014
Antigen signal strength during priming determines effector CD4 T cell function and antigen sensitivity during influenza virus challenge.
Journal of immunology (Baltimore, Md. : 1950)
Nagaoka M,Hatta Y,Kawaoka Y,Malherbe LP
48-0112 was used in Flow cytometry/Cell sorting to compare CD4 T cell responses induced by peptides displaying varying binding half-lives with MHC class II before and after influenza virus infection.
Mon Sep 15 00:00:00 EDT 2014
Influence of PhoP and intra-species variations on virulence of Yersinia pseudotuberculosis during the natural oral infection route.
PloS one
Pisano F,Heine W,Rosenheinrich M,Schweer J,Nuss AM,Dersch P
48-0112 was used in Flow cytometry/Cell sorting to investigate the role of PhoP in oral infections, showing that virulence of Yersinia pseudotuberculosis is influenced by PhoP and intra-species variations.
Thu Nov 12 00:00:00 EST 2015
Cervico-vaginal immunoglobulin G levels increase post-ovulation independently of neutrophils.
PloS one
Schaefer K,Brown N,Kaye PM,Lacey CJ
48-0112 was used in Flow cytometry/Cell sorting to conclude that neutrophil influx and IgG accumulation are independent events that occur in the FRT during the reproductive cycle.
Mon Apr 25 00:00:00 EDT 2016
The mucosal adjuvant cyclic di-AMP exerts immune stimulatory effects on dendritic cells and macrophages.
PloS one
Škrnjug I,Rueckert C,Libanova R,Lienenklaus S,Weiss S,Guzmán CA
48-0112 was used in Flow cytometry/Cell sorting to assess changes in cell surface marker expression of dendritic cells and macrophages in response to c-di-AMP.
Wed Jan 14 00:00:00 EST 2015
Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.
Development (Cambridge, England)
Tober J,Yzaguirre AD,Piwarzyk E,Speck NA
48-0112 was used in Flow cytometry/Cell sorting to study how the requirements for Runx1 in erythroid/myeloid progenitors and hematopoietic stem cell formation are temporally distinct.
Sun Sep 01 00:00:00 EDT 2013
CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Ehrentraut H,Clambey ET,McNamee EN,Brodsky KS,Ehrentraut SF,Poth JM,Riegel AK,Westrich JA,Colgan SP,Eltzschig HK
48-0112 was used in Flow cytometry/Cell sorting to determine how CD73-dependent adenosine generation in Tregs promotes ALI resolution.
Sat Jun 01 00:00:00 EDT 2013
Interleukin-27 receptor limits atherosclerosis in Ldlr-/- mice.
Circulation research
Koltsova EK,Kim G,Lloyd KM,Saris CJ,von Vietinghoff S,Kronenberg M,Ley K
48-0112 was used in Flow cytometry/Cell sorting to establish a novel role for IL-27 receptor signalling in limiting arterial inflammation and atherosclerosis.
Fri Oct 26 00:00:00 EDT 2012
CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs.
Journal of immunology (Baltimore, Md. : 1950)
Pagán AJ,Pepper M,Chu HH,Green JM,Jenkins MK
48-0112 was used in Flow cytometry/Cell sorting to track polyclonal peptide:MHCII-specific CD4+ T cells in vivo, in mice with mutations in two sites within the cytoplasmic tail of CD28.
Sat Sep 15 00:00:00 EDT 2012
Ethyl pyruvate ameliorates endotoxin-induced corneal inflammation.
Investigative ophthalmology & visual science
Gupta D,Du Y,Piluek J,Jakub AM,Buela KA,Abbott A,Schuman JS,SundarRaj N
48-0112 was used in Flow cytometry/Cell sorting to demonstrate that EP reduces LPS-induced inflammation in the cornea.
Tue Sep 25 00:00:00 EDT 2012
Klf4 regulates the expression of Slurp1, which functions as an immunomodulatory peptide in the mouse cornea.
Investigative ophthalmology & visual science
Swamynathan S,Buela KA,Kinchington P,Lathrop KL,Misawa H,Hendricks RL,Swamynathan SK
48-0112 was used in Flow cytometry/Cell sorting to examine the corneal expression and functions of the secreted Ly6/uPAR-related protein-1.
Wed Dec 19 00:00:00 EST 2012
Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation.
Cell host & microbe
Jensen KD,Wang Y,Wojno ED,Shastri AJ,Hu K,Cornel L,Boedec E,Ong YC,Chien YH,Hunter CA,Boothroyd JC,Saeij JP
48-0112 was used in Flow cytometry/Cell sorting to investigate how Toxoplasma-secreted effectors work to achieve chronic infection.
Thu Jun 16 00:00:00 EDT 2011
CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice.
The Journal of clinical investigation
Medina-Contreras O,Geem D,Laur O,Williams IR,Lira SA,Nusrat A,Parkos CA,Denning TL
48-0112 was used in Flow cytometry/Cell sorting to investigate the relative contributions of different APC populations in IBD, showing that CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses.
Thu Dec 01 00:00:00 EST 2011
IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis.
The Journal of experimental medicine
Zhao J,Zhao J,Fett C,Trandem K,Fleming E,Perlman S
48-0112 was used in Flow cytometry/Cell sorting to show that pathogen epitope-specific Foxp3(+) T reg cells can be identified on the basis of cytokine production.
Mon Aug 01 00:00:00 EDT 2011
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.
The Journal of experimental medicine
Mortensen M,Soilleux EJ,Djordjevic G,Tripp R,Lutteropp M,Sadighi-Akha E,Stranks AJ,Glanville J,Knight S,Jacobsen SE,Kranc KR,Simon AK
48-0112 was used in Flow cytometry/Cell sorting to show that Atg7 is an essential regulator of adult hematopoietic stem cell maintenance.
Mon Mar 14 00:00:00 EDT 2011
Pathogenic bacteria and dead cells are internalized by a unique subset of Peyer's patch dendritic cells that express lysozyme.
Gastroenterology
Lelouard H,Henri S,De Bovis B,Mugnier B,Chollat-Namy A,Malissen B,Méresse S,Gorvel JP
48-0112 was used in Flow cytometry/Cell sorting to investigate the expression of lysozyme in the Peyer's patches, showing that pathogenic bacteria and dead cells are internalised by a unique subset of dendritic cells expressing lysozyme.
Fri Jan 01 00:00:00 EST 2010
Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells.
Journal of immunology (Baltimore, Md. : 1950)
Tomihara K,Guo M,Shin T,Sun X,Ludwig SM,Brumlik MJ,Zhang B,Curiel TJ,Shin T
48-0112 was used in Flow cytometry/Cell sorting to investigate CD11b(+)Gr-1(+) cells found in epithelial ovarian cancer-bearing mice, which are induced by ovarian cancer cells and undergo antigen-specific immunity and cross-priming.
Tue Jun 01 00:00:00 EDT 2010
Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Whiteland JL,Nicholls SM,Shimeld C,Easty DL,Williams NA,Hill TJ
Wed Mar 01 00:00:00 EST 1995