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CD137 (4-1BB) Antibody (MA5-42580) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of CD137 (green) in LOVO cells using CD137 (4-1BB) Monoclonal Antibody (Product # MA5-42580). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
产品信息
MA5-42580
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2G1
抗原
Recombinant full length protein
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2911721
产品详细信息
Positive Control: A431, A549, LOVO, rat brain tissue, rat hippocampus tissue, human liver cancer tissue, mouse brain tissue, human tonsil tissue, Jurkat.
Subcellular Location: Membrane. Extracellular space.
靶标信息
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 4 1 BB; 4-1BB ligand receptor; 41BB; CD137; CD137 antigen; CDw137; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB; T-cell antigen 4-1BB homolog; T-cell antigen ILA; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9
基因别名: 4-1BB; A930040I11Rik; AA408498; AI325004; CD137; CDw137; ILA; Ly63; TNFRSF9
UniProt ID: (Human) Q07011, (Mouse) P20334
Entrez Gene ID: (Human) 3604, (Mouse) 21942, (Rat) 500590
apoptotic process
inflammatory response
immune response
multicellular organism development
negative regulation of cell proliferation
extrinsic apoptotic signaling pathway via death domain receptors
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
regulation of apoptotic process
protein homotrimerization
negative regulation of interleukin-10 secretion
negative regulation of interleukin-12 secretion
regulation of cell proliferation
