Invitrogen

CD137 Monoclonal Antibody (4B4-1), Alexa Fluor™ 647

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CD137 Antibody (A51019) in Flow

Histogram plot of lymphocytes from lysed whole blood cells stained for 20 minutes with CD137-Alexa Fluor® 647; x-axis: CD137-Alexa Fluor® 647 fluorescence, y-axis: count.

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产品信息

A51019

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

5 µL/1x10^6 cells

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产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

4B4-1

抗原

Recombinant human CD137 ectodomain

偶联物

Alexa Fluor™ 647 Alexa Fluor™ 647 Alexa Fluor™ 647

激发/发射光谱

650/671 nm 查看光谱

形式

Liquid

浓度

0.04 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.0325% sodium azide

保存条件

4° C, store in dark

运输条件

Ambient

RRID

AB_2633303

靶标信息

CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Product References

A systematic safety pipeline for selection of T-cell receptors to enter clinical use.

NPJ vaccines

Foldvari Z,Knetter C,Yang W,Gjerdingen TJ,Bollineni RC,Tran TT,Lund-Johansen F,Kolstad A,Drousch K,Klopfleisch R,Leisegang M,Olweus J

A51019 was used in Flow Cytometry to assess TCR-T off-target reactivity.

Tue Aug 22 00:00:00 EDT 2023

Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants.

Cell reports

Meyer S,Blaas I,Bollineni RC,Delic-Sarac M,Tran TT,Knetter C,Dai KZ,Madssen TS,Vaage JT,Gustavsen A,Yang W,Nissen-Meyer LSH,Douvlataniotis K,Laos M,Nielsen MM,Thiede B,Søraas A,Lund-Johansen F,Rustad EH,Olweus J

A51019 was used in flow cytometry to conclude that comprehensive mapping of epitope prevalence does not provide evidence that mutations in VOC are driven by escape of T cell immunity.

Tue Jan 31 00:00:00 EST 2023

Anti-tumour immunity induces aberrant peptide presentation in melanoma.

Nature

Bartok O,Pataskar A,Nagel R,Laos M,Goldfarb E,Hayoun D,Levy R,Körner PR,Kreuger IZM,Champagne J,Zaal EA,Bleijerveld OB,Huang X,Kenski J,Wargo J,Brandis A,Levin Y,Mizrahi O,Alon M,Lebon S,Yang W,Nielsen MM,Stern-Ginossar N,Altelaar M,Berkers CR,Geiger T,Peeper DS,Olweus J,Samuels Y,Agami R

A51019 was used in Flow Cytometry to investigate the effects of prolonged IFNγ treatment on mRNA translation.

Mon Feb 01 00:00:00 EST 2021

生物信息学

蛋白别名: 4 1 BB; 4-1BB ligand receptor; 41BB; CD137; CD137 antigen; CDw137; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9

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基因别名: 4-1BB; CD137; CDw137; ILA; TNFRSF9

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UniProt ID: (Human) Q07011

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Entrez Gene ID: (Human) 3604

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功能

receptor activity tumor necrosis factor-activated receptor activity cytokine binding transmembrane signal receptor

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