Product References
CD137 signaling in Hodgkin and Reed-Sternberg cell lines induces IL-13 secretion, immune deviation and enhanced growth.
Oncoimmunology
Rajendran S,Ho WT,Schwarz H
MA5-13739 was used in Immunohistochemistry to validate CD137 as a candidate target for immunotherapy of HL.
Wed Jun 01 00:00:00 EDT 2016
Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity.
Blood
Lee-Chang C,Bodogai M,Moritoh K,Olkhanud PB,Chan AC,Croft M,Mattison JA,Holst PJ,Gress RE,Ferrucci L,Hakim F,Biragyn A
MA5-13739 was used in Functional assay to propose that 4BL cells and the 4-1BBL signaling pathway are useful targets for improved effectiveness of natural antitumor defenses and therapeutic immune manipulations in the elderly.
Thu Aug 28 00:00:00 EDT 2014
Expression of CD137 on Hodgkin and Reed-Sternberg cells inhibits T-cell activation by eliminating CD137 ligand expression.
Cancer research
Ho WT,Pang WL,Chong SM,Castella A,Al-Salam S,Tan TE,Moh MC,Koh LK,Gan SU,Cheng CK,Schwarz H
MA5-13739 was used in immunohistochemistry to study the role of CD137 on Hodgkin and Reed-Sternberg cells in the mechanism by which they inhibit the activation of T-cells
Tue Jan 15 00:00:00 EST 2013
CD137 is expressed in follicular dendritic cell tumors and in classical Hodgkin and T-cell lymphomas: diagnostic and therapeutic implications.
The American journal of pathology
Anderson MW,Zhao S,Freud AG,Czerwinski DK,Kohrt H,Alizadeh AA,Houot R,Azambuja D,Biasoli I,Morais JC,Spector N,Molina-Kirsch HF,Warnke RA,Levy R,Natkunam Y
MA5-13739 was used in immunohistochemistry to study the diagnostic and therapeutic importance of CD137 expression by follicular dendritic cell tumors and Hodgkin and T-cell lymphomas
Sat Sep 01 00:00:00 EDT 2012
Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment.
Blood
Alizadeh AA,Gentles AJ,Alencar AJ,Liu CL,Kohrt HE,Houot R,Goldstein MJ,Zhao S,Natkunam Y,Advani RH,Gascoyne RD,Briones J,Tibshirani RJ,Myklebust JH,Plevritis SK,Lossos IS,Levy R
MA5-13739 was used in immunohistochemistry to study the expression of genes reflecting tumor and microenvironment and their value in predicting survival in diffuse large B-cell lymphoma
Thu Aug 04 00:00:00 EDT 2011
CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells.
Blood
Baessler T,Charton JE,Schmiedel BJ,Grünebach F,Krusch M,Wacker A,Rammensee HG,Salih HR
MA5-13739 was used in flow cytometry to study the role of CD137 ligand in NK-cell reactivity against human acute myeloid leukemia cells
Thu Apr 15 00:00:00 EDT 2010
CD137 enhances monocyte-ICAM-1 interactions in an E-selectin-dependent manner under flow conditions.
Molecular immunology
Quek BZ,Lim YC,Lin JH,Tan TE,Chan J,Biswas A,Schwarz H
MA5-13739 was used in flow cytometry to study the role of CD137 in monocyte recruitment to inflammation
Sat May 01 00:00:00 EDT 2010
Induction of proliferation and monocytic differentiation of human CD34+ cells by CD137 ligand signaling.
Stem cells (Dayton, Ohio)
Jiang D,Yue PS,Drenkard D,Schwarz H
MA5-13739 was used in immunohistochemistry to investigate the influence of CD137 on CD34+ cell amplification and differentiation
Mon Sep 01 00:00:00 EDT 2008
Molecular mechanisms and gene regulation of melphalan- and hyperthermia-induced apoptosis in Ewing sarcoma cells.
Anticancer research
Krause C,Klüttermann K,Mauz-Körholz C
MA5-13739 was used in blocking or activating experiment to study the mechanisms underlying melphalan- and hyperthermia-induced apoptosis in Ewing sarcoma cells
Tue Dec 16 00:00:00 EST 2008