Invitrogen

CD16/CD30 Humanized (Bi-specific) Recombinant Human Monoclonal Antibody (AFM13)

产品信息

MA562424

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

Assay-dependent

酶联免疫吸附实验 (ELISA)

Assay-dependent

功能检测 (Functional)

Assay-dependent

产品规格

种属反应

Human

宿主/亚型

Human / VH-VL-VH-VL

Expression System

CHO cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

AFM13

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

CD16 and CD30 are important targets in immunotherapy particularly for the treatment of various cancers. CD16 also known as Fc gamma receptor III is primarily expressed on natural killer (NK) cells and macrophages and is involved in antibody-dependent cellular cytotoxicity (ADCC) wherein effector cells recognize antibody-coated target cells. Biosimilars targeting CD16 are utilized to enhance the efficacy of therapeutic antibodies by optimizing interactions with NK cells. Polymorphisms in CD16 could influence the effectiveness of these therapies as seen in studies evaluating different CD16 variants. CD30 on the other side is predominantly expressed in lymphoma cells such as Hodgkin lymphoma and anaplastic large cell lymphoma making it a significant target for antibody-drug conjugates (ADCs) and CAR-T cell therapies. Anti-CD30 therapies utilize monoclonal antibodies or engineered T cells to specifically target and destroy CD30-expressing tumor cells. Research into biosimilars or related compounds such as those utilizing CD30 with CD3 bispecific antibodies seeks to improve specificity and reduce off-target effects leveraging the restricted nature of CD30 expression in healthy tissues. This highlights the therapeutic potential and advancements in the use of biosimilars targeting CD16 and CD30 in oncology.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: CD16-II; CD16a; CD16a antigen; CD30; CD30L receptor; cytokine receptor CD30; Fc fragment of IgG low affinity IIIa receptor; Fc fragment of IgG, low affinity III, receptor for (CD16); Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Fc gamma receptor III; Fc gamma receptor III-A; Fc gamma receptor IIIa; Fc-gamma receptor III-2 (CD 16); Fc-gamma receptor IIIb (CD16); Fc-gamma RIII; Fc-gamma RIII-alpha; Fc-gamma RIIIa; FcgammaRIIIA; FcR-10; IgG Fc receptor III-2; IgG Fc receptor III-A; immunoglobulin G Fc receptor III; Ki-1; Ki-1 antigen; Low affinity immunoglobulin gamma Fc region receptor III-A; Lymphocyte activation antigen CD30; lymphocyte antigen; neutrophil-specific antigen NA; Tumor necrosis factor receptor superfamily member 8; tumor necrosis factor receptor superfamily, member 8

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基因别名: CD16; CD16A; CD30; D1S166E; FCG3; FCGR3; FCGR3A; FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20; Ki-1; TNFRSF8

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UniProt ID: (Human) P08637, (Human) P28908

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Entrez Gene ID: (Human) 2214, (Human) 943

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功能

IgG binding transmembrane signaling receptor activity tumor necrosis factor-activated receptor activity immunoglobulin receptor superfamily transmembrane signal receptor

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