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Invitrogen
CD1c Monoclonal Antibody (L161)
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CD1c Antibody (MA562230) in Flow
Flow cytometry (surface staining) of CD1c in human peripheral whole blood. Samples were incubated with CD1c monoclonal antibody (Product # MA562230) using a dilution of 0.33 µg/mL. Separation of human CD1c positive CD19 positive lymphocytes (red-filled) from neutrophil granulocytes (black-dashed).
产品信息
MA562230
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
L161
抗原
Human thymocytes.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
15mM sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CD1c is a member of the CD1 family of transmembrane glycoproteins, which are structurally related to major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. This family of proteins is involved in the presentation of lipid and glycolipid antigens, both of self and microbial origin, to T cells during the adaptive immune response. CD1c is expressed on some circulating and marginal zone B cells, as well as in lymph nodes and germinal centers. It plays a crucial role in presenting lipid antigens, such as microbial fatty acids, to effector T cells. The protein encoded by the CD1c gene localizes to late endosomes and lysosomes, utilizing a tyrosine-based motif in its cytoplasmic tail for targeting. Vesicular acidification is required for CD1c to bind lipid antigens effectively. The human genome contains five CD1 family genes organized in a cluster on chromosome 1, with each member differing in cellular localization and specificity for particular lipid ligands. CD1c undergoes alternative splicing, resulting in three different isoforms: soluble, membrane-bound, and cytoplasmic/soluble isoforms, highlighting its functional diversity in immune processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD1c; CD1C antigen, c polypeptide; cortical thymocyte antigen CD1C; differentiation antigen CD1-alpha-3; RP11-101J8.3; T-cell surface glycoprotein CD1c
基因别名: BDCA1; CD1; CD1A; CD1C; R7
UniProt ID: (Human) P29017
Entrez Gene ID: (Human) 911
