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Invitrogen
CD1d Monoclonal Antibody (51.1), Alexa Fluor™ 647
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CD1d Antibody (MA562231) in Flow
Flow cytometry (surface staining) of CD1d in human peripheral whole blood. Samples were stained with CD1d monoclonal antibody (Product # MA562231) using a dilution of 4 µL reagent/100 µL of peripheral whole blood. Separation of human CD1d positive lymphocytes (red-filled) from CD1d negative lymphocytes (black-dashed).
产品信息
MA562231
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Non-human primate
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
51.1
抗原
Human CD1d.
偶联物
激发/发射光谱
650/671 nm
查看光谱
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Size-exclusion chromatography
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
15mM sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CD1d is a heavy chain associated with Beta 2 microglobulin on cortical thymocytes. Beta 2 microglobulin independent expression of CD1d has also been demonstrated on human intestinal epithelial cells. CD1d is the sole group 2 member of the CD1 family of major histocompatibility (MHC) like glycoproteins. The CD1d gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by the CD1d gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Diseases associated with CD1D include Mycobacterium Malmoense and Autoimmune Disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Antigen-presenting glycoprotein CD1d; CD1d; CD1D antigen, d polypeptide; differentiation antigen CD1-alpha-3; HMC class I antigen-like glycoprotein CD1D; R3G1; T-cell surface glycoprotein CD1d; thymocyte antigen CD1D
基因别名: CD1A; CD1D; R3; R3G1
UniProt ID: (Human) P15813
Entrez Gene ID: (Human) 912
viral process
detection of bacterium
heterotypic cell-cell adhesion
positive regulation of T cell proliferation
T cell selection
innate immune response
positive regulation of innate immune response
antigen processing and presentation, endogenous lipid antigen via MHC class Ib
antigen processing and presentation, exogenous lipid antigen via MHC class Ib
regulation of immune response
